Concentration-Dependent Photoproduction of Singlet Oxygen by Common Photosensitizers

被引：0

作者：

Szewczyk, Grzegorz ^{[1
]}

Mokrzynski, Krystian ^{[1
]}

机构：

[1] Jagiellonian Univ Krakow, Fac Biophys Biochem & Biotechnol, Dept Biophys, PL-30387 Krakow, Poland

来源：

MOLECULES | 2025年 / 30卷 / 05期

关键词：

singlet oxygen; quantum yield; photosensitizers; methylene blue; TMPyP; perinaphthenone; ZnPc; Eosin Y; Rose Bengal; aggregation; QUANTUM YIELDS; AGGREGATION; GENERATION;

D O I：

10.3390/molecules30051130

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Singlet oxygen quantum yield (Phi Delta) is a critical parameter in photodynamic studies, particularly for evaluating photosensitizers' efficiency in diverse applications such as photodynamic therapy and environmental remediation. Standard photosensitizers, including Rose Bengal, Methylene Blue, and porphyrins, are widely employed as benchmarks for determining Phi Delta. However, accurate determination of Phi Delta relies not only on the intrinsic properties of these photosensitizers but also on their experimental conditions, such as concentration. This study investigated the influence of photosensitizer concentration on singlet oxygen quantum yield using several standard photosensitizers. Our findings revealed a significant decrease in Phi Delta with increasing photosensitizer concentrations across all tested compounds. This decline was attributed to self-quenching effects and molecular aggregation, which reduced the efficiency of energy transfer from the excited triplet state of the photosensitizer to molecular oxygen. The results emphasize the importance of optimizing photosensitizer concentration to ensure reliable Phi Delta measurements and avoid underestimations. This work underscores the need to consider concentration-dependent effects in future studies to ensure accurate and reproducible outcomes.

引用

页数：11

共 22 条

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