Original Mechanistic study of Erianin in alopecia areata

被引：0

作者：

Xuan, Xiaomei ^{[2
,3
,4
]}

Zhang, Guoqiang ^{[2
,3
,4
]}

Zhang, Jinfang ^{[2
,3
,4
]}

Zhu, Qing ^{[2
,3
,4
]}

Zhang, Yuli ^{[2
,3
,4
]}

Liu, Lijuan ^{[2
,3
,4
]}

Peng, Dandan ^{[2
,3
,4
]}

Wang, Dongxue ^{[2
,3
,4
]}

Liu, Yaling ^{[1
]}

机构：

[1] Hebei Med Univ, Hosp 3, Dept Dermatol, Shijiazhuang 050051, Hebei, Peoples R China

[2] Hebei Med Univ, Hosp 1, Dept Dermatol, Shijiazhuang 050031, Hebei, Peoples R China

[3] Subctr Natl Clin Res Ctr Skin & Immune Dis, Shijiazhuang 050031, Hebei, Peoples R China

[4] Hebei Prov Innovat Ctr Dermatol & Med Cosmetol Tec, Shijiazhuang 050031, Hebei, Peoples R China

来源：

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2025年 / 17卷 / 01期

关键词：

Erianin; alopecia areata (AA); mechanism; immune regulation; C3H/HEJ MICE; CELLS;

D O I：

10.62347/DHJM6411

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: To investigate the role and mechanisms of Erianin in treating alopecia areata. Methods: A C3H/HeJ AA mouse model was established using skin transfer or adoptive T-cell transfer. All mice received either systemic or topical treatments. Photographic documentation was used to monitor hair growth, which was quantified using G*Power software. Infiltrating inflammatory markers in the skin were assessed using immunofluorescence staining, and the infiltrating immune cell populations in the skin and subcutaneous draining lymph nodes (SDLNs) were analyzed using flow cytometry. Results: Erianin effectively inhibited the function of effector T cells, significantly suppressing Alopecia Areata (AA) in C3H/HeJ transplanted mice. It also reversed systemic manifestations of AA and effectively promoted hair growth in AA mice. Conclusion: Erianin demonstrates a potent therapeutic effect on AA, primarily through modulation of T cell immune function.

引用

页码：550 / 559

页数：10

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