Interactions Between BMP2/BMP4 Gene Polymorphisms and Fluoride Exposure on Essential Hypertension: A Cross-Sectional Study in China

被引：0
作者：
Gao, Yue [1 ,2 ]
Wang, Qingbo [1 ,2 ]
Wu, Junhua [1 ,2 ]
Liu, Yang [1 ,2 ]
Wang, Xin [1 ,2 ]
Gao, Yanhui [1 ,2 ]
Yang, Yanmei [1 ,2 ]
机构：
[1] Harbin Med Univ, Ctr Endem Dis Control, Chinese Ctr Dis Control & Prevent, 157 Baojian Rd, Harbin 150081, Peoples R China
[2] Harbin Med Univ, Educ Bur Heilongjiang Prov, Key Lab Etiol & Epidemiol, Minist Hlth PR China, Harbin 150081, Peoples R China
来源：
TOXICS | 2025年 / 13卷 / 02期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
fluoride; hypertension; BMP2/4; single nucleotide polymorphism; gene-environment interaction; SODIUM-FLUORIDE; CELLS; SMOOTH; BMP4;
D O I：
10.3390/toxics13020126
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
(1) Objective: To evaluate the relationship between fluoride exposure, interactions of BMP2/BMP4 gene polymorphisms, and fluoride exposure on essential hypertension. (2) Methods: A cross-sectional study was conducted among 725 participants in a high-fluoride region of Shanxi Province, China. Urinary fluoride concentrations were measured as indicators of fluoride exposure. Hypertension was diagnosed based on standard guidelines. BMP2 (rs1005464) and BMP4 (rs17563) polymorphisms were genotyped. Logistic regression and interaction models were performed to evaluate associations and interactions between fluoride exposure, gene polymorphisms, and hypertension. (3) Results: Higher urinary fluoride concentrations were significantly associated with an increased risk of hypertension, exhibiting a dose-dependent relationship. The rs1005464 (G > A) polymorphism of BMP2 was identified as a protective factor against hypertension in individuals with the AG + AA genotype. Significant interactions were observed between the BMP2 rs1005464 and BMP4 rs17563 polymorphisms, influencing hypertension risk. Additionally, both multiplicative and additive interactions between high fluoride exposure and the BMP4 rs17563 polymorphism were identified, highlighting the combined impact of environmental and genetic factors on hypertension. (4) Conclusions: Fluoride exposure is positively associated with hypertension. BMP2 gene polymorphisms affect the risk of hypertension, and BMP4 gene polymorphisms may modify the impact of fluoride on hypertension.
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页数：12
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