Electrochemical C3-Fluoroalkoxylation of Quinoxalin-2(1H)-ones with Fluoroalkyl Alcohols for the Synthesis of 3-Fluoroalkoxylated Quinoxalin-2(1H)-ones

被引：0
|
作者：
Liu, Yuan-Yuan [1 ]
Chen, Lu [1 ]
Wang, Ting [1 ]
Wang, Guoqin [1 ]
Zhang, Minmin [2 ]
Jing, Linhai [1 ]
Han, Pan [1 ]
Zhang, Zheng-Bing [1 ]
机构：
[1] China West Normal Univ, Chem Synth & Pollut Control Key Lab Sichuan Prov, Nanchong 637002, Peoples R China
[2] Lunan Pharmaceut Grp Co Ltd, Natl Engn Technol Res Ctr Chiral Pharmaceut, Linyi 276005, Shandong, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 27卷 / 34期
关键词：
electrochemical synthesis; C-H fluoroalkoxylation; radical coupling; quinoxalin-2(1H)-ones; environmental friendliness; AEROBIC C3-H FLUOROALKOXYLATION; C-H FUNCTIONALIZATION; QUINOXALINONE; DERIVATIVES; INHIBITORS; CATALYSIS;
D O I：
10.1002/ejoc.202400628
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report the first electricity-driven and metal-free C(3)-H fluoroalkoxylation of quinoxalin-2(1H)-ones with both alpha-monosubstituted and alpha,alpha-disubstituted fluoroalkyl alcohols. This strategy features the advantages of convenience, mildness, effEctiveness and broad substrate practicality for synthesizing a new type of 3-fluoroalkoxylated quinoxalin-2(1H)-ones.
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页数：6
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