Absolute signal of stimulated Raman scattering microscopy: A quantum electrodynamics treatment

被引:2
|
作者
Min, Wei [1 ]
Gao, Xin [1 ]
机构
[1] Columbia Univ, Dept Chem, New York, NY 10027 USA
来源
SCIENCE ADVANCES | 2024年 / 10卷 / 50期
关键词
SENSITIVITY; LIQUIDS; TIME;
D O I
10.1126/sciadv.adm8424
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The advent of stimulated Raman scattering (SRS) microscopy has launched a rapidly growing field in chemical imaging with broad impact. Although the physical picture seems to be well understood from classical models, prediction of absolute SRS signals remains a challenge. Here, we present a quantum electrodynamics treatment of the newly introduced stimulated Raman cross section. The resulting formula for calculating the absolute SRS signal is simple and differs from the commonly used relations by only one factor. We demonstrate the utility of this formula in a broad range of crucial applications of SRS microscopy, including stimulated Raman enhancement factor (>10(8) times), signal-to-noise ratio (SNR) of typical imaging experiments, population saturation under high power excitation, and energy deposition during stimulated Raman photothermal microscopy. In particular, the theory predicts that SRS microscopy is almost always more sensitive than spontaneous Raman microscopy for chemical imaging.
引用
收藏
页数:10
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