Seroprevalence of anti-SARS-CoV-2 IgM and IgG and COVID-19 vaccine uptake in healthy volunteers in Nairobi, Kenya: a cross-sectional study

被引:0
作者
Otindo, Agnes Muhonja [1 ]
Ndombi, Eric M. [2 ]
Theuri, Martin [1 ]
Muturi, Margaret [1 ]
Thamaini, Peris [3 ]
Ogutu, James [2 ]
Onsongo, Lister [4 ]
Madete, June K. [5 ]
Ofula, Victor [6 ]
Gitau, Samuel [7 ]
Mwangi, Gladys [7 ]
Okemo, Paul [8 ]
机构
[1] Kenyatta Univ, Dept Med Lab Sci, Nairobi, Kenya
[2] Kenyatta Univ, Dept Med Microbiol & Parasitol, Nairobi, Kenya
[3] Kenyatta Univ, Dept Human Pathol, Nairobi, Kenya
[4] Kenyatta Univ, Dept Community & Reprod Hlth Nursing, Nairobi, Kenya
[5] Kenyatta Univ, Dept Elect & Elect Engn, Nairobi, Kenya
[6] Kenya Govt Med Res Ctr, CTR VIRUS RES, NAIROBI, Kenya
[7] Kenyatta Univ, Dept Pharmacol & Clin Pharm, Nairobi, Kenya
[8] Kenyatta Univ, Dept Biochem Biotechnol & Microbiol, Nairobi, Kenya
来源
FRONTIERS IN VIROLOGY | 2024年 / 4卷
基金
新加坡国家研究基金会;
关键词
COVID-19; hesitancy; IgG; IgM; mistrust; SARS-CoV-2; seroprevalence; vaccination;
D O I
10.3389/fviro.2024.1479645
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Introduction: Seroprevalence of anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) antibodies in the postvaccination period in Kenya remains to be elucidated. This study aimed to determine the seroprevalence of anti-SARS-CoV-2 IgM and IgG and evaluate Covid-19 vaccination uptake in a university setting in Nairobi. Methods: This cross-sectional study assayed serum anti-SARS-CoV-2 IgM and IgG levels using enzyme-linked immunosorbent assays. A structured questionnaire was used to determine vaccine uptake, vaccine hesitancy and reasons for hesitancy. Results: A total of 189 participants were enrolled (median age, 21 years; female, 50.8%). The seroprevalence of anti-SARS-CoV-2 was 12.7% for IgM and 87.8% for IgG. Anti-SARS-CoV-2 IgG titers were higher among the vaccinated vs. non-vaccinated individuals (p < 0.001, U = 2817.5), females vs. males (p = 0.024, U = 3616), and those vaccinated <= 6 months before the study vs. those vaccinated >1 year earlier (p = 0.002, H = 12.359). The vaccination hesitancy rate was 43.4% and the underlying reasons included mistrust (22.4%), health concerns (19.7%), and lack of information (18.4%). Discussion: The high seroprevalence of anti-SARS-CoV-2 IgG is an indication of high exposure to SARS-CoV-2 either through natural infection or through vaccination. The high vaccine hesitancy noted necessitates community engagement, and public education to dispel myths and misinformation prior to roll out of new vaccines and other health interventions.
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页数:10
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