Bullous pemphigoid in a patient with psoriasis after mRNA COVID-19 vaccination

被引：0
作者：
Merilleno, Arbie Sofia P. [1 ]
Quizon, Mae R. [1 ]
Legaspi, Kristine Natalee M. [2 ]
机构：
[1] Rizal Med Ctr, Dept Dermatol, Pasig Blvd, Pasig 1600, Metro Manila, Philippines
[2] St Gabriel Med Ctr, Dept Dermatol, Aklan, Philippines
来源：
JEADV CLINICAL PRACTICE | 2023年 / 2卷 / 01期
关键词：
bullous pemphigoid; case report; mRNA COVID-19 vaccination; Pfizer; psoriasis;
D O I：
10.1002/jvc2.88
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Bullous pemphigoid and psoriasis are two well-characterised chronic autoimmune diseases that may be triggered by drugs, infections or vaccines. The coexistence of the two is a rare event but is more extraordinary if incited by messenger RNA (mRNA) COVID-19 vaccination. A 62-year-old Filipino male experiencing a flare-up of his long-standing psoriasis vulgaris presented with new onset tense blisters on the legs 2 days after his first booster dose of mRNA (Pfizer-BioNTech) vaccination. The clinical, skin punch biopsy, direct immunofluorescence and enzyme-linked immunosorbent assay were consistent with bullous pemphigoid. Complete resolution of the vesicles and bullae with no new lesions and flattening of psoriasis plaques were observed after 1 month of treatment of systemic corticosteroids and corticosteroid-sparing agents. An association may exist between bullous pemphigoid development and mRNA COVID-19 vaccination.
引用
收藏
页码：152 / 155
页数：4
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