Evaluation of the Antibacterial Activity of Cinnamic Acid and Its Derivatives: Synergistic Effects with Cloxacillin

被引：0
作者：
Zawila, Tomasz [1 ]
Swolana, Denis [1 ]
Rok, Jakub [2 ]
Rzepka, Zuzanna [2 ]
Wojtyczka, Robert D. [1 ]
机构：
[1] Med Univ Silesia, Fac Pharmaceut Sci Sosnowiec, Dept Microbiol, Ul Jagiellonska 4, PL-41200 Sosnowiec, Poland
[2] Med Univ Silesia, Fac Pharmaceut Sci Sosnowiec, Dept Pharmaceut Chem, Ul Jagiellonska 4, PL-41200 Sosnowiec, Poland
来源：
MOLECULES | 2025年 / 30卷 / 03期
关键词：
antimicrobial activity; biofilm; cinnamic acid; <italic>Staphylococcus epidermidis</italic>; confocal microscopy; BIOFILM;
D O I：
10.3390/molecules30030660
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Staphylococcus epidermidis is a widely prevalent microorganism whose key virulence factors include a high ability to adhere to synthetic surfaces and the capacity to form biofilms. The widespread distribution of multidrug-resistant strains (e.g., MRSE-methycillin-resistant Staphylococcus epidermidis) compels researchers to explore new therapeutic approaches. Cinnamic acid and its derivatives are common plant-derived compounds known for their broad range of biological activities, including antimicrobial properties. The phenotypic assays conducted in this study revealed a strong anti-biofilm activity of the investigated compounds. Confocal laser scanning microscopy allowed for the visualization of structural changes within the biofilm and facilitated the assessment of bacterial cell viability in relation to the concentration of the tested substances.
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页数：12
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