Evaluation of a probiotic blend on psychosocial health and biomarkers of inflammatory, immune and stress response in adults with subthreshold depression: a double-blind, randomised, placebo-controlled trial

被引：2

作者：

Moschonis, George ^{[1
,2
]}

Sarapis, Katerina ^{[1
]}

Resciniti, Stephanie ^{[1
]}

Hall, Renate ^{[1
]}

Yim, Kanny ^{[1
]}

Tonkovic, Matilda ^{[1
]}

Fitzgerald, Clare ^{[1
]}

Anixiadis, Fay ^{[1
]}

Vinh, Antony ^{[3
,4
]}

Dinh, Quynh Nhu ^{[3
,4
]}

Cronin, Rachael A. ^{[5
]}

Hale, Matthew W. ^{[6
]}

Wright, Bradley J. ^{[6
]}

Pane, Marco ^{[7
]}

Tuck, Caroline J. ^{[1
,8
]}

Biesiekierski, Jessica R. ^{[1
,9
]}

机构：

[1] La Trobe Univ, Sch Allied Hlth Human Serv & Sport, Dept Sport Exercise & Nutr Sci, Discipline Food Nutr & Dietet, Melbourne, Vic 3086, Australia

[2] La Trobe Univ, La Trobe Inst Sustainable Agr & Food LISAF, Melbourne, Vic 3086, Australia

[3] La Trobe Univ, La Trobe Inst Med Sci LIMS, Ctr Cardiovasc Biol & Dis Res CCBDR, Melbourne, Vic 3086, Australia

[4] La Trobe Univ, Sch Agr Biomed & Environm, Dept Microbiol Anat Physiol & Pharmacol, Melbourne, Vic 3086, Australia

[5] La Trobe Univ, Dept Psychol Counselling & Therapy, Albury Wodonga, Vic 3690, Australia

[6] La Trobe Univ, Dept Psychol Counselling & Therapy, Melbourne, Vic 3086, Australia

[7] Probiot Res Srl, I-28100 Novara, Italy

[8] Swinburne Univ, Dept Nursing & Allied Hlth, Melbourne, Vic 3122, Australia

[9] Monash Univ, Dept Nutr Dietet & Food, Melbourne, Vic 3168, Australia

来源：

BRITISH JOURNAL OF NUTRITION | 2024年

关键词：

Depression; Subthreshold depression; Anxiety; Probiotics; Lactobacillus; QUALITY-OF-LIFE; PRIMARY-CARE; SUBSYNDROMAL DEPRESSION; MINOR DEPRESSION; MAJOR DEPRESSION; SYMPTOMS; ANXIETY; METAANALYSIS; PREVALENCE; RISK;

D O I：

10.1017/S0007114524001703

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

This study examined the efficacy of a probiotic in reducing depressive symptom severity in people with subthreshold depression. In a double-blind, randomised, placebo-controlled trial, a probiotic (1 x 10<^>9 live cells per strain: Limosilactobacillus fermentum LF16 (DSM26956), Lacticaseibacillus rhamnosus LR06 (DSM21981), Lactiplantibacillus plantarum LP01 (LMG P-21021) and Bifidobacterium longum 04 (DSM23233)) or placebo was taken daily for 12 weeks. Data were collected at baseline, 6 and 12 weeks including psychological symptom severity (Beck Depression Inventory, BDI; Patient Health Questionnaire, PHQ; Hospital Anxiety Depression Scale, HADS; and Depression Anxiety and Stress Scale, DASS). Biomarkers of glycaemia, inflammation (high-sensitivity C-reactive protein, hs-CRP), antioxidant status (total glutathione (GSH)) and stress (cortisol awakening response, CAR) were also measured. Thirty-nine participants (nineteen probiotic; twenty placebo) were enrolled. There were no significant between-group differences in the examined psychological symptom severity scores, despite certain significant within-group changes observed in both groups from baseline to 6 and/or 12 weeks of follow-up. Regarding biomarkers, the probiotic group showed reduced hs-CRP (-1520; 95 % CI -273<middle dot>7, -2766<middle dot>2 ng/dl) and CAR (-0<middle dot>28; 95 % CI -0<middle dot>05, -0<middle dot>51 mu g/dl) at 12 weeks, but increased total GSH (3<middle dot>9; 95 % CI 0<middle dot>1, 7<middle dot>5 ng/dl) at 6 weeks, compared with the placebo. The current study reported favourable decreases in depressive symptoms in both groups. Although the within-group changes observed in the probiotic group were supported by favourable inflammatory, antioxidant status and stress biomarker changes compared with the placebo, further research is required to shed more light on the role of gut microbiota modulation on emotional regulation.

引用

页数：15

共 62 条

[31] Effect of Psychobiotics on Psychometric Tests and Inflammatory Markers in Major Depressive Disorder: Meta-Analysis of Randomized Controlled Trials with Meta-Regression [J].