Atroposelective synthesis of N-N axially chiral pyrrolylamides by combined-acid catalytic Paal-Knorr reaction

被引：0
|
作者：
Chen, Zhihuang [1 ]
Chen, Qi [1 ]
Tu, Guogang [1 ]
Xiong, Xiaodong [1 ]
机构：
[1] Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2025年 / 61卷 / 26期
基金：
中国国家自然科学基金;
关键词：
PYRROLES;
D O I：
10.1039/d4cc06721e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A general and efficient method for the construction of enantiomerically pure N-N axially chiral pyrrolylamides by utilizing the catalytic asymmetric Paal-Knorr reaction has been developed. The key to success is the use of the binary-acid catalytic system involving the dramatic synergistic effect of a Lewis acid and a chiral phosphoric acid for achieving effective stereocontrol.
引用
收藏
页码：5007 / 5010
页数：4
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