Classification and bibliometric analysis of hydrogels in periodontitis treatment: Trends, mechanisms, advantages, and future research directions

Objectives: The review assess the potential of hydrogel-based drug delivery systems in treating periodontitis. Hydrogels are classified based on source, composition, configuration, crosslinking methods, ionic charge, and response to stimuli. Methods: The methodology comprised of comprehensive data collection from WoS, Scopus and PubMed databases covering the period of 2004-2024 of 626 documents. A bibliometric analysis was conducted using VOS Viewer to identify research trends, key contributors, prominent topics, and leading journals. A comparative analysis was performed to examine the benefits of hydrogels over conventional periodontitis treatments. Current research and innovations in hydrogel formulations were reviewed, including ongoing clinical trials and commercial products. Results: China was found to be the leading contributor to hydrogel research in periodontitis, with key topics including "hydrogels," "nanoparticles," and "drug delivery." A detailed classification system for hydrogels was established, aiding in their application for targeted drug delivery and tissue regeneration. Hydrogels were found to offer controlled drug release, support for tissue regeneration, and improved clinical outcomes compared to traditional treatments. Innovations highlighted including the use of various polymers like nano-hydroxyapatite/ collagen composites, PLGA-based materials, and chitosan gels in clinical trials, demonstrating enhanced cell proliferation and tissue regeneration. Significance: This review underscores the significant potential of hydrogel-based therapies in advancing the treatment of periodontitis. By providing a comprehensive bibliometric analysis and highlighting key research and innovations, it emphasizes the advantages of hydrogels in terms of targeted drug delivery, minimal invasiveness, and support for tissue regeneration. The findings suggest that with further clinical trials and regulatory approvals, hydrogels could become a mainstream, effective treatment option for periodontitis, offering improved patient outcomes and potentially transforming periodontal therapy.