Current insights on mitochondria-associated endoplasmic reticulum membranes (MAMs) and their significance in the pathophysiology of ocular disorders

被引：0
|
作者：
Zhang, Xin-Yu [1 ]
Han, Cheng [1 ]
Yao, Yong [1 ]
Wei, Ting-Ting [2 ]
机构：
[1] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Ophthalmol, Wuxi Med Ctr, Wuxi, Peoples R China
[2] Nanjing Med Univ, Wuxi Peoples Hosp, Ctr Clin Res, Wuxi Med Ctr, Wuxi, Peoples R China
来源：
EXPERIMENTAL EYE RESEARCH | 2024年 / 248卷
关键词：
Eye diseases; Mitochondria-associated endoplasmic; reticulum membranes; Pathophysiology; RETINAL-PIGMENT EPITHELIUM; GLOBAL PREVALENCE; OXIDATIVE STRESS; ECONOMIC BURDEN; ER; MITOPHAGY; FISSION; PHOSPHATIDYLSERINE; MECHANISMS; DYNAMICS;
D O I：
10.1016/j.exer.2024.110110
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The intricate interaction network necessary for essential physiological functions underscores the interdependence among eukaryotic cells. Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs), specialized junctions between mitochondria and the ER, were recently discovered. These junctions participate in various cellular processes, including calcium level regulation, lipid metabolism, mitochondrial integrity maintenance, autophagy, and inflammatory responses via modulating the structure and molecular composition of various cellular components. Therefore, MAMs contribute to the pathophysiology of numerous ocular disorders, including Diabetic Retinopathy (DR), Age-related Macular Degeneration (AMD) and glaucoma. In addition to providing a concise overview of the architectural and functional aspects of MAMs, this review explores the key pathogenetic pathways involving MAMs in the development of several ocular disorders.
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页数：11
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