Exploring the potential anticancer targets and mechanistic pathways of Elsholtzia densa essential oil based on network pharmacology

被引：0
|
作者：
Wang, Qian [1 ]
Wang, Xiao-Ying [2 ]
Tao, Jin [1 ]
Nie, Jin-Tao [1 ]
Zhou, Yi-Han [1 ]
Huang, Jing [1 ]
Zhao, Jia-Yuan [1 ]
Wang, Ya-Nan [1 ]
机构：
[1] Sichuan Normal Univ, Sch Life Sci, Chengdu 610101, Peoples R China
[2] Suzhou Vocat Hlth Coll, Sch Med Technol, Suzhou 215009, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2025年
关键词：
<italic>Elsholtzia densa</italic>; essential oil; network pharmacology; antitumor; CANCER; PROMOTES; CARCINOMA; MIGRATION; INVASION; CELLS; GROWTH; EGFR;
D O I：
10.1080/10286020.2024.2446294
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
This study aimed to assess the composition of Elsholtzia densa essential oil (EBE) and identify potential targets for inhibiting human hepatocellular carcinoma cell proliferation. The plants were collected from four regions: Jiuzhi, Qinghai; Ruoergai, Sichuan; Aba, Sichuan; and Jiulong, Sichuan. Four EBEs (named No. 1 to No. 4) were analyzed by gas chromatograph-mass spectrometer. EBEs significantly inhibited human hepatocellular carcinoma cells. The EBE collected from Jiuzhi exhibited the most potent inhibitory effect. Core targets identified included MAPK3, EGFR, ESR1, CASP3, PTGS2, BCL2L1, and MAPK14. Notably, the four EBEs prevented hepatocellular carcinoma cell proliferation via neuroactive ligand-receptor interactions and apoptosis pathways.
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页数：20
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