Trends and Disparities in Coronary Artery Disease and Obesity-Related Mortality in the United States From 1999-2022

被引:5
作者
Ahmed, Mushood [1 ]
Javaid, Hira [2 ]
Shafiq, Aimen [3 ]
Nadeem, Zain Ali [2 ]
Ahsan, Areeba [4 ]
Nofal, Abdullah [5 ]
Ahmed, Raheel [6 ,7 ]
Alam, Mahboob [8 ]
Fudim, Marat [9 ,10 ]
Fonarow, Gregg C. [11 ]
Mamas, Mamas A. [12 ]
机构
[1] Rawalpindi Med Univ, Dept Med, Rawalpindi, Pakistan
[2] Allama Iqbal Med Coll, Dept Med, Lahore, Pakistan
[3] Dow Univ Hlth Sci, Dept Med, Karachi, Pakistan
[4] Fdn Univ Med Coll, Dept Med, Islamabad, Pakistan
[5] Serv Inst Med Sci, Dept Med, Lahore, Pakistan
[6] Imperial Coll London, Natl Heart & Lung Inst, London, England
[7] Royal Brompton Hosp, Dept Cardiol, London, England
[8] Baylor Coll Med, Texas Heart Inst, Div Cardiol, Houston, TX USA
[9] Duke Univ, Med Ctr, Dept Med, Durham, NC USA
[10] Duke Clin Res Inst, Durham, NC USA
[11] Univ Calif Los Angeles, Ahmanson UCLA Cardiomyopathy Ctr, Div Cardiol, Los Angeles, CA USA
[12] Keele Univ, Ctr Prognosis Res, Keele Cardiovasc Res Grp, Stoke On Trent, England
关键词
CDC WONDER; coronary artery disease; mortality; obesity; CARDIOVASCULAR-DISEASE; HEART-DISEASE; EPIDEMIOLOGY;
D O I
10.1002/edm2.70010
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundAlmost half of the US adult population has obesity, which predisposes to atherosclerosis and can lead to poor prognosis in coronary artery disease (CAD). We aim to identify CAD and obesity-related mortality trends among adults in the United States stratified by age, sex, race and geographical location.MethodsThe CDC-WONDER database was used to extract death certificate data for adults aged >= 25 years. Crude mortality rates (CMR) and age-adjusted mortality rates (AAMRs) per 100,000 persons were calculated, and temporal trends were described by calculating annual percent change (APC) and the average APC (AAPC) in the rates using Joinpoint regression analysis.ResultsFrom 1999 to 2022, a total of 273,761 CAD and obesity-related deaths were recorded in the United States. The AAMR increased consistently from 1999 to 2018 (APC: 4.3, 95% confidence interval (CI): 3.4-4.9) and surged thereafter till 2022 (APC: 11.4; 95% CI: 7.7-19.1). During the COVID-19 pandemic (2020-2022), AAMR almost doubled that of the rest of the study period. Additionally, the AAMR for males was nearly twice that of females. Non-Hispanic (NH) Blacks or African Americans displayed the highest AAMR, followed by NH Whites, Hispanic or Latino, and other NH populations. AAMRs showed minimal variation by census regions. Rural areas exhibited a higher AAMR (AAMR: 5.9, 95% CI: 5.8-5.9) than urban areas (AAMR: 4.4, 95% CI: 4.4-4.5).ConclusionsWe observed increasing trends in CAD and obesity-related deaths throughout the study period reaching a peak during the COVID-19 pandemic.
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页数:7
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