TransTACs: Transforming antibodies into targeted protein degraders

被引：0
作者：
Guo, Yu [1 ,2 ]
Che, Jinxin [1 ,2 ]
Dong, Xiaowu [1 ,2 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China
[2] Zhejiang Univ, State Key Lab Adv Drug Delivery & Release Syst, Hangzhou 310058, Peoples R China
来源：
ACTA PHARMACEUTICA SINICA B | 2025年 / 15卷 / 02期
关键词：
Targeted protein degradation; Membrane and extracellular proteins; Transferrin receptor-targeting chimeras; Protein homeostasis regulation; Tumor therapy; DEGRADATION; PROTACS;
D O I：
10.1016/j.apsb.2025.01.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：1186 / 1188
页数：3
相关论文
共 50 条
  • [31] Protein-Protein Interaction Prediction for Targeted Protein Degradation
    Orasch, Oliver
    Weber, Noah
    Mueller, Michael
    Amanzadi, Amir
    Gasbarri, Chiara
    Trummer, Christopher
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (13)
  • [32] The 17th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders
    Ciulli, Alessio
    O'Connor, Suzanne
    Chung, Chun-Wa
    Hartung, Ingo V.
    Testa, Andrea
    Daniels, Danette L.
    Heitman, Laura H.
    CHEMMEDCHEM, 2023, 18 (20)
  • [33] Comparative analysis of biophysical methods for monitoring protein proximity induction in the development of small molecule degraders
    Przytulski, Kamil
    Glaza , Przemyslaw
    Brach, Katarzyna
    Sagan, Maria
    Statkiewicz, Grzegorz
    Klajn, Jan
    Walczak , Michal J.
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023, 1867 (09):
  • [34] Protein degraders enter the clinic - a new approach to cancer therapy
    Chirnomas, Deborah
    Hornberger, Keith R.
    Crews, Craig M.
    NATURE REVIEWS CLINICAL ONCOLOGY, 2023, 20 (04) : 265 - 278
  • [35] Fluorescent probes and degraders of the sterol transport protein Aster-A
    He, Nianzhe
    Depta, Laura
    Sievers, Sonja
    Laraia, Luca
    BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 103
  • [36] Photoactive Bifunctional Degraders: Precision Tools To Regulate Protein Stability
    Kounde, Cyrille S.
    Tate, Edward W.
    JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (24) : 15483 - 15493
  • [37] Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders
    Kroupova, Alena
    Spiteri, Valentina A.
    Rutter, Zoe J.
    Furihata, Hirotake
    Darren, Darren
    Ramachandran, Sarath
    Chakraborti, Sohini
    Haubrich, Kevin
    Pethe, Julie
    Gonzales, Denzel
    Wijaya, Andre J.
    Rodriguez-Rios, Maria
    Sturbaut, Manon
    Lynch, Dylan M.
    Farnaby, William
    Nakasone, Mark A.
    Zollman, David
    Ciulli, Alessio
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [38] Targeted protein degradation and drug discovery
    Naito, Mikihiko
    JOURNAL OF BIOCHEMISTRY, 2022, : 61 - 69
  • [39] Utilizing Alkyne-Nitrone Cycloaddition for the Convenient Multi-Component Assembly of Protein Degraders and Biological Probes
    Lin, Shiou-Ting
    Wang, Chien-Hua
    Chen, Ai-Lin
    Wang, Tsung-Shing Andrew
    CHEMISTRY-A EUROPEAN JOURNAL, 2025, 31 (03)
  • [40] Research Progress of Targeted Protein Degradation Technology
    Zhang Xiao-Yuan
    Zhang Yan-Yan
    Sun Xiao-Kang
    Zhang Lin-Jun
    Chen Mian
    Liu Fei
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2022, 49 (01) : 171 - 182
12345