TransTACs: Transforming antibodies into targeted protein degraders

被引：0
作者：
Guo, Yu [1 ,2 ]
Che, Jinxin [1 ,2 ]
Dong, Xiaowu [1 ,2 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China
[2] Zhejiang Univ, State Key Lab Adv Drug Delivery & Release Syst, Hangzhou 310058, Peoples R China
来源：
ACTA PHARMACEUTICA SINICA B | 2025年 / 15卷 / 02期
关键词：
Targeted protein degradation; Membrane and extracellular proteins; Transferrin receptor-targeting chimeras; Protein homeostasis regulation; Tumor therapy; DEGRADATION; PROTACS;
D O I：
10.1016/j.apsb.2025.01.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：1186 / 1188
页数：3
相关论文
共 50 条
  • [1] Recent advances in developing targeted protein degraders
    Cheng, Binbin
    Li, Hongqiao
    Peng, Xiaopeng
    Chen, Jianjun
    Shao, Chuxiao
    Kong, Zhihua
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 284
  • [2] Clinical Translation of Targeted Protein Degraders
    Kong, Nikki R.
    Jones, Lyn H.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2023, 114 (03) : 558 - 568
  • [3] Targeted Protein Degraders- The Druggability Perspective
    Singh, Satinder
    Srivastava, Pratima
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2024, 113 (03) : 539 - 554
  • [4] Central Nervous System Targeted Protein Degraders
    Thomas, Bedwyr ab Ion
    Lewis, H. Lois
    Jones, D. Heulyn
    Ward, Simon E.
    BIOMOLECULES, 2023, 13 (08)
  • [5] Targeted protein knockdown using small molecule degraders
    Raina, Kanak
    Crews, Craig M.
    CURRENT OPINION IN CHEMICAL BIOLOGY, 2017, 39 : 46 - 53
  • [6] Recent advances in targeted protein degraders as potential therapeutic agents
    Yang, Na
    Kong, Bo
    Zhu, Zhaohong
    Huang, Fei
    Zhang, Liliang
    Lu, Tao
    Chen, Yadong
    Zhang, Yanmin
    Jiang, Yulei
    MOLECULAR DIVERSITY, 2024, 28 (01) : 309 - 333
  • [7] Recent advances in targeted protein degraders as potential therapeutic agents
    Na Yang
    Bo Kong
    Zhaohong Zhu
    Fei Huang
    Liliang Zhang
    Tao Lu
    Yadong Chen
    Yanmin Zhang
    Yulei Jiang
    Molecular Diversity, 2024, 28 : 309 - 333
  • [8] Simplifying Access to Targeted Protein Degraders via Nickel Electrocatalytic Cross-Coupling
    Neigenfind, Philipp
    Massaro, Luca
    Peter, Aron
    Degnan, Andrew P.
    Emmanuel, Megan A.
    Oderinde, Martins S.
    He, Chi
    Peters, David
    El-Hayek Ewing, Tamara
    Kawamata, Yu
    Baran, Phil S.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2024, 63 (16)
  • [9] Applications of Bacterial Degrons and Degraders - Toward Targeted Protein Degradation in Bacteria
    Izert, Matylda Anna
    Klimecka, Maria Magdalena
    Gorna, Maria Wiktoria
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2021, 8
  • [10] Natural Product-Inspired Targeted Protein Degraders: Advances and Perspectives
    Li, Jiao
    Cai, Zhenyu
    Li, Xu-Wen
    Zhuang, Chunlin
    JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (20) : 13533 - 13560
12345