Understanding the Impact of Oxidative Stress on Ovarian Cancer: Advances in Diagnosis and Treatment

被引:1
作者
Meshkovska, Yeva [1 ]
Abramov, Artem [2 ]
Mahira, Shaheen [3 ]
Thatikonda, Sowjanya [1 ]
机构
[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Clin Sci Head & Neck Endocrine Oncol, Tampa, FL 33612 USA
[2] Eurofins Lancaster Labs Inc, Dept QC Microbiol, Rensselaer, NY 12144 USA
[3] Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15213 USA
来源
FUTURE PHARMACOLOGY | 2024年 / 4卷 / 03期
关键词
reactive oxygen species; ovarian cancer; oxidative stress; SIGNALING PATHWAY; PROTEIN OXIDATION; CORPUS-LUTEUM; ACTIVATION; CELLS; NOTCH; TUMORIGENESIS; MECHANISMS; EXPRESSION; GRADE;
D O I
10.3390/futurepharmacol4030035
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Ovarian cancer (OC) ranks as the fifth most common cancer among women in the United States and globally, posing a significant health threat. Reactive oxygen species (ROS) have emerged as critical factors in the pathophysiology of this malignancy. ROS, characterized by their instability due to an unpaired electron, are involved in essential cellular functions and play a crucial role in the immune response under normal physiological conditions. However, an imbalance in ROS homeostasis, leading to excessive ROS production, results in oxidative stress (OS), which can cause indiscriminate damage to cellular structures and contribute to the pathogenesis of specific diseases, including OC. OC is primarily classified based on the originating cell type into epithelial, stromal, and germinal tumors, with epithelial tumors being the most prevalent. Despite advancements in medical technology, early detection of OC remains challenging, often leading to delayed treatment initiation. Current therapeutic approaches include surgical excision of tumor tissue, radiotherapy, and chemotherapy. While these treatments are effective in early-stage OC, high mortality rates and frequent relapse underscore the urgent need for novel diagnostic and therapeutic strategies. This review aims to elucidate the role of ROS in OC, emphasizing the potential for developing innovative diagnostic tools and treatments that target ROS-mediated pathways. Given the critical impact of early detection and effective treatment, advancing our understanding of ROS in the context of OC could significantly enhance patient outcomes.
引用
收藏
页码:651 / 675
页数:25
相关论文
共 50 条
  • [41] Raptor couples mTORC1 and ERK1/2 inhibition by cardamonin with oxidative stress induction in ovarian cancer cells
    Zhu, Yanting
    Wang, Shifeng
    Niu, Peiguang
    Chen, Huajiao
    Zhou, Jintuo
    Jiang, Li
    Li, Danyun
    Shi, Daohua
    PEERJ, 2023, 11
  • [42] A clinical prognostic model of oxidative stress-related genes linked to tumor immune cell infiltration and the prognosis of ovarian cancer patients
    Li, Li
    Zhang, Weiwei
    Sun, Yanjun
    Zhang, Weiling
    Lu, Mengmeng
    Wang, Jiaqian
    Jin, Yunfeng
    Xi, Qinghua
    HELIYON, 2024, 10 (07)
  • [43] Peptides for diagnosis and treatment of ovarian cancer
    Guo, Ling
    Wang, Jing
    Li, Nana
    Cui, Jialin
    Su, Yajuan
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [44] Nanotechnology in ovarian cancer: Diagnosis and treatment
    Barani, Mahmood
    Bilal, Muhammad
    Sabir, Fakhara
    Rahdar, Abbas
    Kyzas, George Z.
    LIFE SCIENCES, 2021, 266
  • [45] Biomarkers in diagnosis and treatment of ovarian cancer
    Rogulski, Lech
    Olejek, Anita
    MENOPAUSE REVIEW-PRZEGLAD MENOPAUZALNY, 2008, 7 (06): : 301 - 307
  • [46] Identification of a ferroptosis- and oxidative stress-associated gene signature for prognostic stratification of ovarian cancer
    Li, Shenyi
    Cao, Tianyue
    Wu, Tiantian
    Xu, Jinfu
    Shen, Cong
    Hou, Shunyu
    Wu, Yibo
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2023, 15 (04): : 2645 - +
  • [47] Failure of Elevating Calcium Induces Oxidative Stress Tolerance and Imparts Cisplatin Resistance in Ovarian Cancer Cells
    Ma, Liwei
    Wang, Hongjun
    Wang, Chunyan
    Su, Jing
    Xie, Qi
    Xu, Lu
    Yu, Yang
    Liu, Shibing
    Li, Songyan
    Xu, Ye
    Li, Zhixin
    AGING AND DISEASE, 2016, 7 (03): : 254 - 266
  • [48] Oxidative stress and apoptosis: a new treatment paradigm in cancer
    Engel, RH
    Evens, AM
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2006, 11 : 300 - 312
  • [49] Tumor is an Oxidative Stress Factor in Ovarian Cancer Patients
    Trifanescu, Oana
    Gruia, Maria Iuliana
    Gales, Laurentia
    Trifanescu, Raluca
    Anghel, Rodica
    CHIRURGIA, 2018, 113 (05) : 687 - 694
  • [50] Emerging strategies to overcome ovarian cancer: advances in immunotherapy
    Pimenta, Tatiana Massariol
    de Souza, Josiany Carlos
    Martins, Barbara da Silva
    Butzene, Solenny Maria Silva
    Padilha, Jose Matheus Simoes
    Marcal, Milleny Ganho
    Elias, Guilherme dos Santos
    Rangel, Leticia Batista Azevedo
    FRONTIERS IN PHARMACOLOGY, 2024, 15