Understanding the Impact of Oxidative Stress on Ovarian Cancer: Advances in Diagnosis and Treatment

被引:1
作者
Meshkovska, Yeva [1 ]
Abramov, Artem [2 ]
Mahira, Shaheen [3 ]
Thatikonda, Sowjanya [1 ]
机构
[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Clin Sci Head & Neck Endocrine Oncol, Tampa, FL 33612 USA
[2] Eurofins Lancaster Labs Inc, Dept QC Microbiol, Rensselaer, NY 12144 USA
[3] Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15213 USA
来源
FUTURE PHARMACOLOGY | 2024年 / 4卷 / 03期
关键词
reactive oxygen species; ovarian cancer; oxidative stress; SIGNALING PATHWAY; PROTEIN OXIDATION; CORPUS-LUTEUM; ACTIVATION; CELLS; NOTCH; TUMORIGENESIS; MECHANISMS; EXPRESSION; GRADE;
D O I
10.3390/futurepharmacol4030035
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Ovarian cancer (OC) ranks as the fifth most common cancer among women in the United States and globally, posing a significant health threat. Reactive oxygen species (ROS) have emerged as critical factors in the pathophysiology of this malignancy. ROS, characterized by their instability due to an unpaired electron, are involved in essential cellular functions and play a crucial role in the immune response under normal physiological conditions. However, an imbalance in ROS homeostasis, leading to excessive ROS production, results in oxidative stress (OS), which can cause indiscriminate damage to cellular structures and contribute to the pathogenesis of specific diseases, including OC. OC is primarily classified based on the originating cell type into epithelial, stromal, and germinal tumors, with epithelial tumors being the most prevalent. Despite advancements in medical technology, early detection of OC remains challenging, often leading to delayed treatment initiation. Current therapeutic approaches include surgical excision of tumor tissue, radiotherapy, and chemotherapy. While these treatments are effective in early-stage OC, high mortality rates and frequent relapse underscore the urgent need for novel diagnostic and therapeutic strategies. This review aims to elucidate the role of ROS in OC, emphasizing the potential for developing innovative diagnostic tools and treatments that target ROS-mediated pathways. Given the critical impact of early detection and effective treatment, advancing our understanding of ROS in the context of OC could significantly enhance patient outcomes.
引用
收藏
页码:651 / 675
页数:25
相关论文
共 50 条
  • [31] Development of a Prognostic Risk Model Based on Oxidative Stress-Related Genes for Platinum-Resistant Ovarian Cancer Patients
    Su, Huishan
    Hou, Yaxin
    Zhu, Difan
    Pang, Rongqing
    Tian, Shiyun
    Ding, Ran
    Chen, Ying
    Zhang, Sihe
    RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, 2025, 20 (01) : 89 - 101
  • [32] Effects of cigarette smoke extracts on apoptosis and oxidative stress in two models of ovarian cancer in vitro
    Kim, Cho-Won
    Go, Ryeo-Eun
    Hwang, Kyung-A
    Bae, Ok-Nam
    Lee, Kyuhong
    Choi, Kyung-Chul
    TOXICOLOGY IN VITRO, 2018, 52 : 161 - 169
  • [33] The Impact of Controlled Ovarian Stimulation on Serum Oxidative Stress Markers in Infertile Women with Endometriosis Undergoing ICSI
    Da Broi, Michele Gomes
    Ferreira, Elisa Melo
    Andrade, Aline Zyman
    Jordao, Alceu Afonso
    Ferriani, Rui Alberto
    Navarro, Paula Andrea
    ANTIOXIDANTS, 2022, 11 (06)
  • [34] Oxidative stress in prostate cancer
    Khandrika, Lakshmipathi
    Kumar, Binod
    Koul, Sweaty
    Maroni, Paul
    Koul, Hari K.
    CANCER LETTERS, 2009, 282 (02) : 125 - 136
  • [35] Epidemiological overview, advances in diagnosis, prevention, treatment and management of epithelial ovarian cancer in Mexico
    Gallardo-Rincon, Dolores
    Espinosa-Romero, Raquel
    Rosemary Munoz, Wendy
    Mendoza-Martinez, Roberto
    del Villar-Alvarez, Susana
    Onate-Ocana, Luis
    Isla-Ortiz, David
    Pablo Marquez-Manriquez, Juan
    Apodaca-Cruz, Angel
    Meneses-Garcia, Abelardo
    SALUD PUBLICA DE MEXICO, 2016, 58 (02): : 302 - 308
  • [36] Advances in natural products modulating autophagy influenced by cellular stress conditions and their anticancer roles in the treatment of ovarian cancer
    Li, Dongxiao
    Geng, Danbo
    Wang, Min
    FASEB JOURNAL, 2024, 38 (19)
  • [37] Impact of isoflurane on malignant capability of ovarian cancer in vitro
    Luo, X.
    Zhao, H.
    Hennah, L.
    Ning, J.
    Liu, J.
    Tu, H.
    Ma, D.
    BRITISH JOURNAL OF ANAESTHESIA, 2015, 114 (05) : 831 - 839
  • [38] Roles of Oxidative Stress in the Development and Progression of Breast Cancer
    Nourazarian, Ali Reza
    Kangari, Parisa
    Salmaninejad, Arash
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 15 (12) : 4745 - 4751
  • [39] Raptor couples mTORC1 and ERK1/2 inhibition by cardamonin with oxidative stress induction in ovarian cancer cells
    Zhu, Yanting
    Wang, Shifeng
    Niu, Peiguang
    Chen, Huajiao
    Zhou, Jintuo
    Jiang, Li
    Li, Danyun
    Shi, Daohua
    PEERJ, 2023, 11
  • [40] New advances in screening and treatment of ovarian cancer
    Morice, P
    Pautier, P
    Bidart, JM
    BULLETIN DU CANCER, 2003, 90 (01) : 53 - 60