The Impact of Smoking on Ulcerative Colitis and Interaction With Family History: A Population-Based Cohort Study

被引:0
作者
Ahn, Hyeong Sik [1 ,2 ]
Swan, Heather [1 ,2 ]
Kazmi, Sayada Zartasha [3 ]
Kim, Young Shin [4 ]
Hong, Gahwi [2 ]
Choi, Seeun [2 ]
Kang, Taeuk [5 ]
Kim, Minjung [1 ,6 ]
Cha, Jaewoo [6 ]
Hann, Hoo Jae [7 ]
Kim, Hyun Jung [1 ,2 ]
机构
[1] Cochrane Korea, Seoul, South Korea
[2] Korea Univ, Coll Med, Inst Evidence Based Med, Seoul, South Korea
[3] Imperial Coll London, Fac Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England
[4] Cleveland Clin Fdn, Dept Family Med, Cleveland Hts, OH USA
[5] Sungshin Womens Univ, Hlth & Wellness Coll, Seoul, South Korea
[6] Korea Univ, Grad Sch, Dept Publ Hlth, Seoul, South Korea
[7] Ewha Womans Univ, Med Res Inst, Coll Med, Seoul, South Korea
关键词
additive interaction; familial risk; inflammatory bowel disease; smoking; ulcerative colitis; INFLAMMATORY-BOWEL-DISEASE; GENE-ENVIRONMENT INTERACTIONS; RISK-FACTORS; BEHAVIOR; IBD; POLYMORPHISMS; AGGREGATION; KNOWLEDGE; SURGERY; SMOKERS;
D O I
10.1111/jgh.16834
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
BackgroundThe impact of smoking on ulcerative colitis (UC) among Asian populations is controversial, and interactions between genetic factors and smoking are not well studied. We evaluated the association between smoking and UC and assessed interactions between smoking and family history.MethodsUsing the National Health Insurance database, we identified 5.5 million individuals from 2002 to 2019 with information on familial relationships and smoking history. Cox proportional hazard regression was used to examine the association between UC and current/former smoking and estimate familial risk. Interactions between family history and smoking were assessed on an additive scale using relative excess risk due to interaction (RERI).ResultsCurrent smoking was associated with a decreased risk of disease (hazard ratio [HR] 0.53 95% CI 0.49-0.56), whereas former smoking was associated with an increased risk (HR 1.62 95% CI 1.53-1.71), compared to nonsmokers. Familial risk was HR 7.51 (95% CI 6.68-8.48). The protective effect of current smoking was more pronounced among those with a family history, as their combined effect was lower than the sum of their individual risks (HR 4.37 vs. 7.55), whereas the harmful effect of former smoking was more prominent among this group, and their combined effect exceeded the sum of their individual effects (HR 10.20 vs. 8.57), indicating statistically significant interactions (RERI current: -3.18 95% CI -4.89 to -1.47; former: 1.63 95% CI -1.00-4.25).ConclusionThe effects of smoking on UC do not appear to differ between Asian and Western populations. Possible gene-smoking interactions were observed but in opposing directions for current/former smoking.
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页码:446 / 455
页数:10
相关论文
共 34 条
[31]   Smoking and Inflammatory Bowel Disease: A Comparison of China, India, and the USA [J].
Wang, Peiqi ;
Hu, Jun ;
Ghadermarzi, Shadi ;
Raza, Ali ;
O'Connell, Douglas ;
Xiao, Amy ;
Ayyaz, Faraz ;
Zhi, Min ;
Zhang, Yuanqi ;
Parekh, Nimisha K. ;
Lazarev, Mark ;
Parian, Alyssa ;
Brant, Steven R. ;
Bedine, Marshall ;
Truta, Brindusa ;
Hu, Pinjin ;
Banerjee, Rupa ;
Hutfless, Susan M. .
DIGESTIVE DISEASES AND SCIENCES, 2018, 63 (10) :2703-2713
[32]   Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice [J].
Yadav, Pankaj ;
Ellinghaus, David ;
Remy, Gaelle ;
Freitag-Wolf, Sandra ;
Cesaro, Anabelle ;
Degenhardt, Frauke ;
Boucher, Gabrielle ;
Delacre, Myriam ;
Peyrin-Biroulet, Laurent ;
Pichavant, Muriel ;
Rioux, John D. ;
Gosset, Philippe ;
Franke, Andre ;
Schumm, L. Philip ;
Krawczak, Michael ;
Chamaillard, Mathias ;
Dempfle, Astrid ;
Andersen, Vibeke .
GASTROENTEROLOGY, 2017, 153 (02) :550-565
[33]  
Yazdanbod Abbas, 2010, Trop Gastroenterol, V31, P308
[34]   Impact of Genes and the Environment on the Pathogenesis and Disease Course of Inflammatory Bowel Disease [J].
Zhao, Mirabella ;
Burisch, Johan .
DIGESTIVE DISEASES AND SCIENCES, 2019, 64 (07) :1759-1769