Efficacy of praziquantel drug against Schistosoma haematobium and performance of urine reagent strips among pre-and-school aged children during the high transmission season in North-Western Tanzania

被引：1

作者：

Mazigo, Humphrey D. ^{[1
,2
,6
]}

Kayange, Neema ^{[3
,4
]}

Ambrose, Emmanuela E. ^{[3
,4
]}

Zinga, Maria M. ^{[1
,2
]}

Mugassa, Stella ^{[1
,2
]}

Ruganuza, Deodatus ^{[1
,2
]}

Mwingira, Upendo J. ^{[5
]}

Uisso, Cecilia ^{[5
]}

Mutapi, Francesca ^{[6
,7
]}

机构：

[1] Catholic Univ Hlth & Allied Sci, Tackling Infect Benefit Africa Partnership, POB 1464, Mwanza, Tanzania

[2] Catholic Univ Hlth & Allied Sci, Sch Publ Hlth, POB 1464, Mwanza, Tanzania

[3] Bugando Med Ctr, Tackling Infect Benefit Africa Partnership, POB 1370, Mwanza, Tanzania

[4] Bugando Med Ctr, Dept Paediat & Child Hlth, POB 1370, Mwanza, Tanzania

[5] Natl Inst Med Res, Natl Neglected Trop Dis Control Programme, POB 9653,3 Barack Obama Dr, Dar Es Salaam 11101, Tanzania

[6] Univ Edinburgh, Tackling Infect Benefit Africa Partnership, Ashworth Labs, Kings Bldg, Edinburgh, Scotland

[7] Univ Edinburgh, Inst Immunol & Infect Res, Ashworth Labs, Kings Bldg, Edinburgh, Scotland

来源：

ACTA TROPICA | 2024年 / 256卷

基金：

美国国家卫生研究院;

关键词：

Schistosomiasis; Schistosoma haematobium; Praziquantel; Egg reduction rate; Cure rates efficacy; High season; Pre-and-school aged children; Tanzania; INFECTION; CHEMOTHERAPY; PREVALENCE; MORBIDITY; MANSONI;

D O I：

10.1016/j.actatropica.2024.107232

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The World Health Organization calls for schistosomiasis endemic countries to regularly monitor the efficacy of Praziquantel (PZQ) drug, the only antischistosomal drug used for four decades in Tanzania. In response to that call, the current study investigated the efficacy of single dose of PZQ against Schistosoma haematobium during the high transmission season and further assessed, , the sensitivity and specificity of urine reagent strips before and after treatment. The study recruited a total of 2,498-children aged (4-17 years old) who provided a single urine sample that was visually examined for macro-haematuria, then using urine dipstick and urine filtration technique for microhaematuria and the presence of S. haematobium eggs. The baseline prevalence of S. haematobium eggs positive based on urine filtration test was 29.2 % (95 %CI:27.5-31.0) and that of microhaematuria was 43.1 % (95 %CI:41.1-45.0). Of the infected participants, 40.9 % (95 %CI:37.4-44.6) had a heavy intensity of infection and the geometrical mean intensity (GMI) of infection was 33.7 eggs/10mls of urine. A single dose of PZQ reduced the prevalence of infection to 16.2 %, the GMI of infection to 18.8eggs/10mls of urine and that of microhaematuria to 27.9 %. Cure rate and egg reduction rates (ERR) were 83.8 % and 44.3 % respectively. At baseline, the sensitivity and specificity of the urine reagent strips were 59.7 % and 93.8 %, whereas at posttreatment they were 16.7 % and 93.6 %. When PZQ drug is administered during the high transmission season, its efficacy in term of ERR is poor. The urine reagent strips had low sensitivity but high specificity at pre-and- post PZQ treatment.

引用

页数：8