Choroidal macrophages in homeostasis, aging and age-related macular degeneration

被引：0

作者：

Khan, Adnan H. ^{[1
,2
]}

Mulfaul, Kelly ^{[1
,2
]}

机构：

[1] Univ Iowa, Inst Vis Res, Iowa City, IA 52242 USA

[2] Univ Iowa, Dept Ophthalmol & Visual Sci, Iowa City, IA 52242 USA

来源：

EXPERIMENTAL EYE RESEARCH | 2025年 / 250卷

关键词：

Choroid; Macrophage; Immunosenescence; Inflammaging; Age-related macular degeneration; BRUCHS MEMBRANE; PHOTORECEPTOR DEGENERATION; SUBRETINAL MICROGLIA; OXIDATIVE STRESS; UVEAL TRACT; CELLS; SENESCENCE; NEOVASCULARIZATION; INFLAMMATION; EXPRESSION;

D O I：

10.1016/j.exer.2024.110159

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

With increasing age, the optimal functioning of the choroid is essential for efficient removal of waste products formed from photoreceptor renewal. A decline in regulatory elements of the immune system, termed immunosenescence, and the failure of para-inflammation to restore tissue homeostasis can result in the progression of healthy aging to sight-threatening inflammation of the choroid. Macrophages are uniquely situated between the innate and adaptive immune systems, with a high capacity for phagocytosis, recognition of complement components, as well as antigen presentation. In this review, we provide an overview of macrophages and their properties in the healthy choroid and cover the impact of aging, immunosenescence and inflammaging on the function of choroidal macrophages. We will discuss the impact of age on macrophage phenotype and behaviour in the pathophysiology of age-related macular degeneration.

引用

页数：12

共 144 条

[91] Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration [J].

Mulfaul, Kelly ;

Mullin, Nathaniel K. ;

Giacalone, Joseph C. ;

Voigt, Andrew P. ;

DeVore, Melette ;

Stone, Edwin M. ;

Tucker, Budd A. ;

Mullins, Robert F. .

JOURNAL OF PATHOLOGY, 2022, 257 (01) :29-38

[92] Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease [J].

Mullins, RF ;

Russell, SR ;

Anderson, DH ;

Hageman, GS .

FASEB JOURNAL, 2000, 14 (07) :835-846

[93] IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis [J].

Nakamura, Rei ;

Sene, Abdoulaye ;

Santeford, Andrea ;

Gdoura, Abdelaziz ;

Kubota, Shunsuke ;

Zapata, Nicole ;

Apte, Rajendra S. .

NATURE COMMUNICATIONS, 2015, 6

[94] Nonresolving Inflammation [J].

Nathan, Carl ;

Ding, Aihao .

CELL, 2010, 140 (06) :871-882

[95] Secreted Protein Acidic and Rich in Cysteine (SPARC) Exacerbates Colonic Inflammatory Symptoms in Dextran Sodium Sulphate-Induced Murine Colitis [J].

Ng, Yoke-Leng ;

Klopcic, Borut ;

Lloyd, Frances ;

Forrest, Cynthia ;

Greene, Wayne ;

Lawrance, Ian C. .

PLOS ONE, 2013, 8 (10)

[96] The multifunctional choroid [J].

Nickla, Debora L. ;

Wallman, Josh .

PROGRESS IN RETINAL AND EYE RESEARCH, 2010, 29 (02) :144-168

[97] Chemokine Profile and the Alterations in CCR5-CCL5 Axis in Geographic Atrophy Secondary to Age-Related Macular Degeneration [J].

Nielsen, Marie Krogh ;

Subhi, Yousif ;

Molbech, Christopher Rue ;

Falk, Mads Kruger ;

Nissen, Mogens Holst ;

Sorensen, Torben Lykke .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2020, 61 (04)

[98]

Oh H, 1999, INVEST OPHTH VIS SCI, V40, P1891

[99] SENILE MACULAR DEGENERATION - THE INVOLVEMENT OF IMMUNOCOMPETENT CELLS [J].

PENFOLD, PL ;

KILLINGSWORTH, MC ;

SARKS, SH .

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 1985, 223 (02) :69-76

[100] Convergence of Innate and Adaptive Immunity during Human Aging [J].

Pereira, Branca I. ;

Akbar, Arne N. .

FRONTIERS IN IMMUNOLOGY, 2016, 7

← 5 6 7 8 9 10 11 12 13 14 →