The Role of Systemic Health Indicators, Including C-Reactive Protein and eGFR, in Predicting Periodontal Disease: A Longitudinal Study

被引:0
|
作者
Ghanem, Amr Sayed [1 ]
机构
[1] Univ Debrecen, Fac Hlth Sci, Dept Hlth Informat, H-4032 Debrecen, Hungary
关键词
c-reactive protein; estimated glomerular filtration rate; CRP; eGFR; periodontitis; periodontal disease; atherosclerosis; oral disease; dyslipidemia; ASSOCIATION; RISK;
D O I
10.3390/ijms26020741
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
C-reactive protein (CRP) and estimated glomerular filtration rate (eGFR) are key biomarkers reflecting systemic inflammation and metabolic dysfunction. This study explored systemic and oral health indicators, including CRP and eGFR, as potential factors associated with periodontitis, using a longitudinal clinical dataset comprising 23,742 records from patients identified by ICD-10 codes between 2015 and 2022. Univariate Cox analysis and Gompertz models, selected based on AIC and BIC after evaluating alternative models, were employed to assess the predictive roles of CRP and eGFR in periodontitis incidence, adjusting for oral and systemic health factors. Elevated CRP (>15 mg/L) and reduced eGFR (<60 mL/min/1.73 m2) were significant predictors of periodontitis, with hazard ratios (HR) of 1.36 [1.05-1.77] and 1.39 [1.08-1.78], respectively. Atherosclerosis (HR: 2.12 [1.11-4.06]), diseases of the hard tissues of the teeth (HR: 7.30 [5.45-9.78]), and disorders of the teeth and supporting structures (HR: 3.02 [2.05-4.43]) also demonstrated strong predictive associations. CRP and eGFR emerged as potential biomarkers for predicting periodontitis, enabling early interventions to prevent tooth loss and systemic complications. Patients with chronic kidney disease, atherosclerotic heart disease, and lipid metabolism disorders are at higher risk, emphasizing the need for integrated care addressing both systemic and oral health factors.
引用
收藏
页数:16
相关论文
共 50 条
  • [31] Relationship between periodontal disease and C-reactive protein among adults in the atherosclerosis risk in communities study
    Slade, GD
    Ghezzi, EM
    Heiss, G
    Beck, JD
    Riche, E
    Offenbacher, S
    ARCHIVES OF INTERNAL MEDICINE, 2003, 163 (10) : 1172 - 1179
  • [32] The Role of C-Reactive Protein in Atherosclerotic Cardiovascular Disease: An Overview
    Nakou, Eleni S.
    Liberopoulos, Evangelos N.
    Milionis, Haralampos J.
    Elisaf, Moses S.
    CURRENT VASCULAR PHARMACOLOGY, 2008, 6 (04) : 258 - 270
  • [33] Role of C-reactive protein in cerebrovascular disease: a critical review
    Di Napoli, Mario
    Elkind, Mitchell S. V.
    Agustin Godoy, Daniel
    Singh, Puneetpal
    Papa, Francesca
    Popa-Wagner, Aurel
    EXPERT REVIEW OF CARDIOVASCULAR THERAPY, 2011, 9 (12) : 1565 - 1584
  • [34] THE ROLE OF C-REACTIVE PROTEIN TO MEASURE PERIODONTAL INFLAMMATION PRODUCING CORONARY ARTERY DISEASE AND OTHER INFLAMMATORY PROCESSES
    Altieri, P. I.
    Escobales, N.
    Covas, V.
    Sanchez, R.
    Quinones, C.
    Banchs, H. L.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2021, 69 (02) : 490 - 490
  • [35] Connecting the role of C-reactive protein and statins in cardiovascular disease
    Ridker, PM
    CLINICAL CARDIOLOGY, 2003, 26 (04) : 39 - 44
  • [36] The role of C-reactive protein:albumin ratio and neutrophil:lymphocyte ratio in predicting coronary artery disease
    Ozmen, Murat
    CARDIOVASCULAR JOURNAL OF AFRICA, 2024,
  • [37] C-REACTIVE PROTEIN-LEVELS DURING DISEASE EXACERBATIONS AND INFECTIONS IN SYSTEMIC LUPUS-ERYTHEMATOSUS - A PROSPECTIVE LONGITUDINAL-STUDY
    TERBORG, EJ
    HORST, G
    LIMBURG, PC
    VANRIJSWIJK, MH
    KALLENBERG, CGM
    JOURNAL OF RHEUMATOLOGY, 1990, 17 (12) : 1642 - 1648
  • [38] Clinical significance of C-reactive protein in patients on hemodialysis:: A longitudinal study
    Teruel, JL
    Marcen, R
    Ocaña, J
    Fernández-Lucas, M
    Rivera, M
    Tabernero, G
    Ortuño, J
    NEPHRON CLINICAL PRACTICE, 2005, 100 (04): : C140 - C145
  • [39] C-reactive protein in saliva from patients with periodontal disease and acute odontogenic infection
    Pejovic, J
    Mijuskovic, JZ
    CLINICA CHIMICA ACTA, 2005, 355 : S142 - S142
  • [40] Role of C-reactive protein in urological cancers: A useful biomarker for predicting outcomes
    Saito, Kazutaka
    Kihara, Kazunori
    INTERNATIONAL JOURNAL OF UROLOGY, 2013, 20 (02) : 161 - 171