Identification and characteristics of a novel CD8αα T cell subset in a refractory myasthenia gravis patient

被引：0

作者：

Liu, Yujia ^{[1
]}

Sun, Hanxiao ^{[2
]}

Xu, Yingchen ^{[3
]}

Xuan, Binbin ^{[2
]}

Xia, Guofang ^{[4
]}

Tang, Jifeng ^{[2
]}

Lin, Jinpiao ^{[2
]}

Du, Ailian ^{[5
]}

Sheng, Huiming ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Tongren Hosp, Sch Med, Dept Neurol, Shanghai 200336, Peoples R China

[2] Shanghai Jiao Tong Univ, Tongren Hosp, Sch Med, Dept Lab Med, Shanghai 200336, Peoples R China

[3] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

[4] Shanghai Jiao Tong Univ, Peoples Hosp 6, Sch Med Affiliated, Dept Cardiol, Shanghai 200233, Peoples R China

[5] Shanghai Jiao Tong Univ, Songjiang Hosp, Sch Med, Dept Neurol, Shanghai 201699, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2025年 / 400卷

关键词：

CD8 alpha alpha T cell; CD161 neg T cell; MAIT cell; Myasthenia gravis; Thymoma; RECEPTOR; THYMOMA;

D O I：

10.1016/j.jneuroim.2025.578551

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Myasthenia gravis (MG) is an autoimmune disease that impairs neuromuscular transmission. Autoantibodies and cellular immunity mediate the immunopathology of MG, yet the mechanism of CD8+ T cells in this process remains elucidated. In this study, we discovered a novel subset of CD8 alpha alpha+ T cells in the peripheral blood of an 18-year-old Chinese man diagnosed as MG, who has undergone thymectomy and persistent myasthenia crisis. Designated as CD161neg T cell, this subset was characterized by TCR alpha beta+CD8 alpha alpha+PLZF+V alpha 7.2+ but notably lacked CD161, distinct from mucosal-associated invariant T (MAIT) cells known for high CD161. The patient exhibited unusually high levels of CD161neg T cells compared to other MG patients, which fluctuated with infections but not MG severity. RNA sequencing revealed that CD161neg T cells lacked the genes characteristic of mature MAIT cells including CCR6, CXCR6, ZBTB16, and IL18RAP, but expressed cytotoxic T cell-related genes GZMH and IFNG. This study shed new light on the heterogeneity and complexity of CD8 alpha alpha+ T cells in MG patients with thymoma.

引用

页数：9

共 38 条

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