Metabolomic Analysis of Daphnia magna Exposed to Fluoxetine Using HR-MAS NMR

被引：0

作者：

Kim, Hyemin ^{[1
]}

Kim, Seonghye ^{[1
]}

Lee, Sujin ^{[1
]}

Moon, Sojeon ^{[1
]}

Park, Jihwan ^{[1
]}

Park, Gisu ^{[1
]}

Kim, Suhkmann ^{[1
]}

机构：

[1] Pusan Natl Univ, Dept Chem, Busan 46241, South Korea

来源：

JOURNAL OF THE KOREAN MAGNETIC RESONANCE SOCIETY | 2024年 / 28卷 / 04期

关键词：

D; magna; Fluoxetine; HR-MAS NMR; Metabolomics;

D O I：

10.6564/JKMRS.2024.28.4.060

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), enhances serotonin levels in synapses to alleviate depressive symptoms. This study investigates the effects of fluoxetine on the aquatic organism Daphnia magna (D. magna), known for its environmental sensitivity. D. magna was exposed to 100 mu g/L of fluoxetine for 72 hours, and metabolomic changes were examined using high-resolution magic angle spinning (HR-MAS) NMR. A total of twentyeight metabolites were identified. Compared to the control group, fluoxetine exposure resulted in decreased levels of phenylalanine and increased levels of sn-glycero- 3-phosphocholine, inosine, proline, carnosine, and tryptophan.

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页码：60 / 63

页数：4

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共 10 条

[1] Improvements in lipid suppression for 1H NMR-based metabolomics: Applications to solution-state and HR-MAS NMR in natural and in vivo samples [J].

Hassan, Qusai ;

Majumdar, Rudraksha Dutta ;

Wu, Bing ;

Lane, Daniel ;

Tabatabaei-Anraki, Maryam ;

Soong, Ronald ;

Simpson, Myrna J. ;

Simpson, Andre J. .

MAGNETIC RESONANCE IN CHEMISTRY, 2019, 57 (2-3) :69-81

[2] Daphnia magna metabolic profiling as a promising water quality parameter for the biological early warning system [J].

Jeong, Tae Yong ;

Simpson, Myrna J. .

WATER RESEARCH, 2019, 166

[3] Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse [J].

Kummer, Wolfgang ;

Wiegand, Silke ;

Akinci, Sibel ;

Wessler, Ignatz ;

Schinkel, Alfred H. ;

Wess, Jurgen ;

Koepsell, Hermann ;

Haberberger, Rainer V. ;

Lips, Katrin S. .

RESPIRATORY RESEARCH, 2006, 7 (1)

[4] Assessments in biocides with omics approaches to ecosystem [J].

Ma, Scohee ;

Yoon, Dahye ;

Kim, Hyunsu ;

Lee, Hyangjin ;

Kim, Seonghye ;

Lee, Huichan ;

Kim, Jieun ;

Lee, Soojin ;

Lee, Yunsuk ;

Lee, Yujin ;

Kim, Suhkmann .

JOURNAL OF THE KOREAN MAGNETIC RESONANCE SOCIETY, 2018, 22 (04) :91-100

[5] Neurons and Glia Cells in Marine Invertebrates: An Update [J].

Ortega, Arturo ;

Olivares-Banuelos, Tatiana N. .

FRONTIERS IN NEUROSCIENCE, 2020, 14

[6] Oxidative and apoptotic effects of fluoxetine and its metabolite norfluoxetine in Daphnia magna [J].

Over, Sevgi Basalan ;

Guven, Celal ;

Taskin, Eylem ;

Sevgiler, Yusuf .

ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY, 2020, 71 (03) :211-222

[7] Optimization of Expression, Purification, and NMR Measurement for Structural Studies of Syndecan-4 Transmembrane Region [J].

Park, Tae-Joon ;

Lee, Min-Hye ;

Choi, Sung-Sub ;

Kim, Yongae .

JOURNAL OF THE KOREAN MAGNETIC RESONANCE SOCIETY, 2011, 15 (01) :25-39

[8] Fluoxetine effects assessment on the life cycle of aquatic invertebrates [J].

Pery, A. R. R. ;

Gust, M. ;

Vollat, B. ;

Mons, R. ;

Ramil, M. ;

Fink, G. ;

Ternes, T. ;

Garric, J. .

CHEMOSPHERE, 2008, 73 (03) :300-304

[9] L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE ANTAGONIZES SCOPOLAMINE-INDUCED AMNESIA AND ENHANCES HIPPOCAMPAL CHOLINERGIC TRANSMISSION IN THE RAT [J].

SIGALA, S ;

IMPERATO, A ;

RIZZONELLI, P ;

CASOLINI, P ;

MISSALE, C ;

SPANO, P .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 211 (03) :351-358

[10] Choline Alphoscerate (Alpha-Glyceryl-Phosphoryl-Choline) An Old Choline-containing Phospholipid with a Still Interesting Profile As Cognition Enhancing Agent [J].

Traini, Enea ;

Bramanti, Vincenzo ;

Amenta, Francesco .

CURRENT ALZHEIMER RESEARCH, 2013, 10 (10) :1070-1079