Oral edaravone ameliorates myocardial fibrosis in type 2 diabetic rats by TGF-β1/Smad signaling pathway

被引：0
作者：
Zhang, Xiao-Yan [1 ]
Xu, Yong-xuan [1 ]
Xue, Si-Quan [2 ]
Zeng, Yue-Qin [2 ]
Gu, Juan-Hua [2 ]
Zhou, Xin-Fu [3 ,4 ]
Luo, Hai-Yun [1 ,5 ]
Pu, Li-Jin [1 ,6 ]
机构：
[1] Kunming Med Univ, Affiliated Hosp 1, Fac Basic Med Sci, Dept Cardiol, 296 Xichang Rd, Kunming 650032, Peoples R China
[2] Biomed Engn Res Ctr, Yunnan Key Lab Stem Cells & Regenerat Med, 1168 Chunrong West Rd, Kunming 650500, Peoples R China
[3] Suzhou Auzone Biotech, Suzhou, Peoples R China
[4] Univ South Australia, Hlth & Biomed Innovat, Clin & Hlth Sci, 101 Currie St, Adelaide 5001, Australia
[5] Kunming Med Univ, Fac Basic Med Sci, 1168 Chunrong West Rd, Kunming 650500, Peoples R China
[6] Kunming Med Univ, Affiliated Hosp 1, 296 Xichang Rd, Kunming 650032, Peoples R China
来源：
JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2025年 / 39卷 / 03期
关键词：
TGF-beta 1/Smad signaling pathway; Edaravone; Myocardial fibrosis; Type 2 diabetes mellitus; GROWTH-FACTOR-BETA; OXIDATIVE STRESS; CARDIAC FIBROSIS; CARDIOMYOPATHY; ANTIOXIDANT; AUTOPHAGY; DAMAGE; SCAR;
D O I：
10.1016/j.jdiacomp.2025.108976
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Myocardial fibrosis, characterized by increased reactive oxygen species (ROS), is a key pathological feature of diabetic cardiomyopathy (DCM). Although oral edaravone (EDA) shows therapeutic potential in ameliorating myocardial fibrosis in DCM, the precise mechanisms remain unclear. Transcriptome analysis of myocardial tissues revealed a dramatic up-regulation of the TGF-(31/Smad pathway, which was reversed by oral EDA treatment. In vitro studies showed that oral EDA attenuated myocardial fibrosis by inhibiting the TGF-(31/Smad signaling pathway and its downstream fibrosis key factors, Col3a1 and a-SMA. These findings suggest that oral EDA improves myocardial fibrosis in Type 2 diabetes mellitus (T2DM) by inhibiting the TGF-(31/Smad signaling pathway and holds promise as an effective treatment for myocardial fibrosis in DCM.
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页数：11
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共 26 条
  • [1] Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy
    Arumugam, Somasundaram
    Thandavarayan, Rajarajan A.
    Veeraveedu, Punniyakoti T.
    Nakamura, Takashi
    Arozal, Wawaimuli
    Sari, Flori R.
    Giridharan, Vijayasree V.
    Soetikno, Vivian
    Palaniyandi, Suresh S.
    Harima, Meilei
    Suzuki, Kenji
    Nagata, Masaki
    Kodama, Makoto
    Watanabe, Kenichi
    [J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2012, 16 (09) : 2176 - 2185
  • [2] Transforming growth factor-β in renal disease
    Bitzer, M
    Sterzel, RB
    Böttinger, EP
    [J]. KIDNEY & BLOOD PRESSURE RESEARCH, 1998, 21 (01) : 1 - 12
  • [3] Density Functional Theory (DFT) Study of Edaravone Derivatives as Antioxidants
    Borges, Rosivaldo S.
    Queiroz, Auriekson N.
    Mendes, Anna P. S.
    Araujo, Sanderson C.
    Franca, Luiz C. S.
    Franco, Edna C. S.
    Leal, Walace G.
    da Silva, Alberico B. F.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2012, 13 (06) : 7594 - 7606
  • [4] Molecular mechanisms of diabetic cardiomyopathy
    Bugger, Heiko
    Abel, E. Dale
    [J]. DIABETOLOGIA, 2014, 57 (04) : 660 - 671
  • [5] Genetics of diabetes mellitus and diabetes complications
    Cole, Joanne B.
    Florez, Jose C.
    [J]. NATURE REVIEWS NEPHROLOGY, 2020, 16 (07) : 377 - 390
  • [6] Diabetic Cardiomyopathy: The Case for a Role of Fructose in Disease Etiology
    Delbridge, Lea M. D.
    Benson, Vicky L.
    Ritchie, Rebecca H.
    Mellor, Kimberley M.
    [J]. DIABETES, 2016, 65 (12) : 3521 - 3528
  • [7] Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy
    Evangelista, Isabella
    Nuti, Ranuccio
    Picchioni, Tommaso
    Dotta, Francesco
    Palazzuoli, Alberto
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (13)
  • [8] Oxidative stress and autophagy: the clash between damage and metabolic needs
    Filomeni, G.
    De Zio, D.
    Cecconi, F.
    [J]. CELL DEATH AND DIFFERENTIATION, 2015, 22 (03) : 377 - 388
  • [9] Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
    Frye, RA
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 273 (02) : 793 - 798
  • [10] Association of risk factors with type 2 diabetes: A systematic review
    Ismail, Leila
    Materwala, Huned
    Al Kaabi, Juma
    [J]. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021, 19 : 1759 - +
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