Association of thallium exposure in early life with gut microbiota in neonates

被引:0
作者
Zhao, Kunyan [1 ]
Yang, Fei [1 ]
Wu, Mingyang [2 ]
Pan, Xiongfeng [3 ]
Xiang, Shiting [3 ]
Tang, Yan [1 ]
Song, Fengmei [1 ]
Peng, Yunlong [4 ]
Wu, Sha [5 ]
Cao, Yunhui [5 ]
Liu, Caixia [3 ]
Qiu, Jun [3 ]
机构
[1] Univ South China, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China
[2] Cent South Univ, Xiangya Sch Publ Hlth, Dept Maternal & Child Hlth, Changsha 410007, Peoples R China
[3] Cent South Univ, Affiliated Childrens Hosp, Hunan Childrens Hosp, Pediat Res Inst Hunan Prov,Xiangya Sch Med, Changsha 410007, Peoples R China
[4] Soochow Univ, Dept Epidemiol & Hlth Stat, Med Coll, Suzhou 215123, Peoples R China
[5] Univ South China, Hengyang Med Sch, Dept Pediat, Hengyang 421001, Peoples R China
关键词
Thallium; Gut microbiota; Neonate; Early life; HEAVY-METALS; ENVIRONMENT; PREGNANCY; BLOOD; MICE;
D O I
10.1016/j.envpol.2025.125876
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Previous research has found a correlation between heavy metals and gut microbiota in humans. However, there are few population-based studies examining the impact of early life thallium (Tl) exposure on neonatal microbiome. 342 newborns were recruited from Hunan Children's Hospital and subsequently divided into three groups (low, medium, and high) based on the 25th and 75th percentiles of serum Tl concentration. Additionally, the relationship between Tl and gut microbiota was analyzed in subgroups (preterm or full-term neonates). The association between Tl and gut microbiota in neonates was analyzed by Redundancy analysis, Spearman correlation analysis and MaAsLin2. The detection rate of Tl in neonates was 100%, with the median concentration of 0.021 mu g/L. In all neonates, we found significant differences in the Chao1 and ACE indices of alpha-diversity in gut microbiota, and the relative abundances of Bacteroidota and Bacteroidetes were significantly different among groups (p < 0.05). Following the covariate adjustment, Tl was negatively correlated with Gemmatimonadota (Coef = 0.265, p < 0.05) in preterm neonates. In full-term neonates, Tl exhibited a positive correlation with the relative abundance of Robinsoniella (Coef = 0.563, p = 0.009) and a negative correlation with that of Pseudomonas (Coef = - 0.592, p = 0.012). Tryptophan and renin-angiotensin system pathways might exert important roles in Tl exposure. This study indicated that Tl exposure was associated with changes in alpha-diversity and the composition of gut microbiota in neonates, with Gemmatimonadota being predominantly affected in preterm neonates and Robinsoniella and Pseudomonas in full-term neonates.
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页数:12
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