Biological cell response to electric field: a review of equivalent circuit models and future challenges

被引:0
作者
Seyedi, Mirhojjat [1 ]
机构
[1] Univ Queensland, Sch Elect Engn & Comp Sci, St Lucia, Qld 4027, Australia
来源
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS | 2025年 / 11卷 / 02期
关键词
cell structure; circuit model; electrical components; frequency; membrane; pulsed electric field; ACTION-POTENTIALS; ELECTROPORATION; MEMBRANE; TEMPERATURE; SIMULATION; PULSES;
D O I
10.1088/2057-1976/ad8092
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Biological cells, characterized by complex and dynamic structures, demand precise models for comprehensive understanding, especially when subjected to external factors such as electric fields (EF) for manipulation or treatment. This interaction is integral to technologies like pulsed electric fields (PEF), inducing reversible and irreversible structural variations. Our study explores both simplified and sophisticated equivalent circuit models for biological cells under the influence of an external EF, covering diverse cell structures from single- to double-shell configurations. The paper highlights challenges in circuit modeling, specifically addressing the incorporation of reversible or irreversible pores in the membrane during external EF interactions, emphasizing the need for further research to refine technical aspects in this field. Additionally, we review a comparative analysis of the performance and applicability of the proposed circuit models, providing insights into their strengths and limitations. This contributes to a deeper insight of the complexities associated with modeling biological cells under external EF influences, paving the way for enhanced applications in medical and technological domains in future.
引用
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页数:13
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