Metal- and Light-Free Decarboxylative Giese Addition Reaction Facilitated by Hantzsch Ester

被引：0

作者：

Liang, Lei ^{[1
,2
]}

Deng, Xiao-Shan ^{[1
]}

Wang, Jing ^{[1
]}

Jia, Ming ^{[1
]}

Zhu, Xing-Yu ^{[1
]}

Zhang, Yong ^{[1
]}

Yuan, Shuai ^{[1
]}

Wang, Song-Lin ^{[1
]}

Guo, Hai-Ming ^{[2
]}

Niu, Hong-Ying ^{[1
]}

机构：

[1] Henan Inst Sci & Technol, Sch Chem & Chem Engn, Phostdoctoral Res Base, Xinxiang 453003, Henan, Peoples R China

[2] Henan Normal Univ, Sch Chem & Chem Engn, Postdoctoral Res Stn, Xinxiang 453007, Henan, Peoples R China

来源：

ORGANIC LETTERS | 2025年 / 27卷 / 02期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; VISIBLE-LIGHT; CARBOXYLIC-ACIDS; PHOTOREDOX CATALYSIS; ELECTRON-TRANSFER; CONJUGATE ADDITIONS; C(SP(3))-H BONDS; BETA-ALKYLATION; AMINO RADICALS; DERIVATIVES;

D O I：

10.1021/acs.orglett.4c04496

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a novel strategy for decarboxylative radical addition reactions that employs ground-state reduced nicotinamide adenine dinucleotide (NADH) analogues under ambient and open-air conditions, facilitating the efficient formation of Csp3-Csp3 bonds in a variety of substrates. This protocol is distinguished by its operational simplicity, mild reaction conditions, high efficiency, and the use of cost-effective starting materials. Furthermore, experimental studies have provided valuable insights into the reaction mechanism, elucidating the light-independent pathways that promote these transformations.

引用

页码：663 / 668

页数：6

共 59 条

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