Ameliorative Role of the Extract of W. coagulans (WCE) Fruits Against Sodium Fluoride-Induced Hepatotoxicity in Mice

被引：0

作者：

Fatima, Areeja ^{[1
]}

Batool, Aima Iram ^{[1
]}

Ikram, Javaria ^{[1
]}

Shoaib, Uswa ^{[1
]}

Zahra, Aiman ^{[1
]}

Fayyaz-ur-Rehman, Muhammad ^{[2
]}

Naveed, Naima Huma ^{[3
]}

Inayat, Iram ^{[1
]}

Tariq, Namra ^{[1
]}

Bibi, Hakim

Habib, Syed Skinadar

Kazimi, Syed Gohar Taqi ^{[1
,4
]}

Kanwal, Muhammad Ali ^{[1
]}

机构：

[1] Univ Sargodha, Dept Zool, Sargodha 40100, Pakistan

[2] Univ Sargodha, Dept Chem, Sargodha, Pakistan

[3] Univ Sargodha, Dept Bot, Sargodha, Pakistan

[4] Govt Ambala Muslim Grad Coll, Sargodha, Pakistan

来源：

FLUORIDE | 2025年 / 58卷 / 03期

关键词：

Sodium fluoride; Withania coagulans; Hepatotoxicity; Hematology;

D O I：

暂无

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Purpose: To investigate the potential protective effects of Withania coagulans extract along with the histological, biochemical, and micrometric alterations in the liver of mice exposed to NaF. Methods: Forty-five male albino mice were distributed into three groups: control group was given saline and a balanced meal without any additional NaF. The NaF and Withania coagulans combination treatment (NWCT) group was given the Withania coagulans extract in addition to fluoridated drinking water. Sodium fluoride treated group (NaF) was provided with fluoridated drinking water for 10 days, after which they were euthanized. After 10 days, every animal was killed in order to remove their organs. Each group's liver was taken out and examined under a microscope. Micrometric measurements were also taken from various sections of each group. Additionally, blood samples from each group were also obtained to estimate the level of bilirubin and alkaline phosphatase in order to perform liver function tests (LFTs), along with complete blood count (CBC) to evaluate hematological parameters. Results: In NaF treated group various histopathological alterations in the liver (such as enormously enlarged hepatocytes, disruption of hepatic cords) were observed. Significant micrometric changes accompanied pathological signs. Biochemical results also displayed significant difference between the three groups. The group treated with Withania coagulans exhibited milder pathological changes in contrast to the NaF group. Conclusions: These findings lead to the conclusion that administration of sodium fluoride caused degenerative morphological changes and damage to the liver and that Withania coagulans extract possesses a shielding effect against NaFinduced hepatotoxicity.

引用

页数：10