Circadian Rhythm Disruption Exacerbates Autoimmune Uveitis: The Essential Role of PER1 in Treg Cell Metabolic Support for Stability and Function

被引：0

作者：

Zhu, Wenjie ^{[1
]}

Chen, Guanyu ^{[1
]}

Xiao, Zhiqiang ^{[1
]}

Wang, Minzhen ^{[1
]}

Li, Zhuang ^{[1
]}

Shi, Yuxun ^{[1
]}

Luo, Xiaohui ^{[1
]}

Li, Zuoyi ^{[1
]}

Huang, Haixiang ^{[1
]}

Chen, Xiaoqing ^{[1
]}

Liang, Lingyi ^{[1
]}

Liang, Dan ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou 510060, Peoples R China

来源：

ADVANCED SCIENCE | 2025年 / 12卷 / 10期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

autoimmune uveitis; cell metabolism; circadian rhythm; PER1; Treg; REV-ERB-ALPHA; T-CELLS; INCREASED RISK; SHIFT WORK; CLOCK; DIFFERENTIATION; ASSOCIATION; GLYCOLYSIS; RESPONSES;

D O I：

10.1002/advs.202400004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Circadian rhythm plays a critical role in the progression of autoimmune diseases. While our previous study demonstrated the therapeutic effects of melatonin in experimental autoimmune uveitis, the involvement of circadian rhythm remained unclear. Using a light-induced circadian rhythm disruption model, we showed that disrupted circadian rhythms exacerbate autoimmune uveitis by impairing the stability and function of Treg cells. Mechanistically, we identified the core clock gene Per1, which is significantly reduced under circadian disruption, is essential for Treg cell metabolism and immunoregulatory function. This study underscores the pivotal role of circadian rhythm-related Treg cells in autoimmune disease progression.

引用

页数：18

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