The Causal Effect of Intrapancreatic Fat Deposition on Acute and Chronic Pancreatitis: A Mendelian Randomization Study

被引：2

作者：

Yamazaki, Hajime ^{[1
,2
]}

Heni, Martin ^{[3
,4
]}

Wagner, Robert ^{[5
,6
,7
]}

Fukuhara, Shunichi ^{[1
,2
,8
]}

Grossman, Steven R. ^{[9
,10
]}

Han, Sihao ^{[11
]}

Wu, Lang ^{[12
]}

Streicher, Samantha A. ^{[12
]}

Huang, Brian Z. ^{[9
,13
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Community Med, Sect Clin Epidemiol, Kyoto, Japan

[2] Fukushima Med Univ, Ctr Innovat Res Communities & Clin Excellence CiRC, Fukushima, Japan

[3] Ulm Univ, Dept Internal Med 1, Div Endocrinol & Diabetol, Ulm, Germany

[4] Univ Hosp Tubingen, Inst Clin Chem & Pathobiochem, Dept Diagnost Lab Med, Tubingen, Germany

[5] Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Dept Endocrinol & Diabetol, Dusseldorf, Germany

[6] Heinrich Heine Univ, Inst Clin Diabetol, German Diabet Ctr DDZ, Leibniz Ctr Diabet Res, Dusseldorf, Germany

[7] German Ctr Diabet Res DZD, Neuherberg, Germany

[8] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD USA

[9] Univ Southern Calif, Norris Comprehens Canc Ctr, Los Angeles, CA USA

[10] Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA USA

[11] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA

[12] Univ Hawaii Manoa, Univ Hawaii, Populat Sci Pacific Program, Canc Epidemiol Div,Canc Ctr, Honolulu, HI USA

[13] Univ Southern Calif, Keck Sch Med, Dept Populat & Publ Hlth Sci, Los Angeles, CA USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2024年 / 119卷 / 12期

关键词：

acute pancreatitis; chronic pancreatitis; intrapancreatic fat deposition; fatty pancreas;

D O I：

10.14309/ajg.0000000000003048

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

INTRODUCTION:Recent associative studies have linked intrapancreatic fat deposition (IPFD) with risk of pancreatitis, but the causal relationship remains unclear.METHODS:Using Mendelian randomization, we evaluated the causal association between genetically predicted IPFD and pancreatitis. This approach used genetic variants from genomewide association studies of IPFD (n = 25,617), acute pancreatitis (n = 6,787 cases/361,641 controls), and chronic pancreatitis (n = 3,875 cases/361,641 controls).RESULTS:Genetically predicted IPFD was significantly associated with acute pancreatitis (odds ratio per 1-SD increase: 1.40 [95% CI: 1.12-1.76], P = 0.0032) and chronic pancreatitis (odds ratio: 1.64 [95% CI: 1.13-2.39], P = 0.0097).DISCUSSION:Our findings support a causal role of IPFD in pancreatitis, suggesting that reducing IPFD could lower the risk of pancreatitis.

引用

页码：2540 / 2544

页数：5

共 15 条

[1] Proteome-Wide Mendelian Randomization Identifies Causal Links Between Blood Proteins and Acute Pancreatitis
Bourgault, Jerome
Abner, Erik
Manikpurage, Hasanga D.
Pujol-Gualdo, Natalia
Laisk, Triin
Gobeil, Emilie
Gagnon, Eloi
Girard, Arnaud
Mitchell, Patricia L.
Theriault, Sebastien
Esko, Tonu
Mathieu, Patrick
Arsenault, Benoit J.
[J]. GASTROENTEROLOGY, 2023, 164 (06) : 953 - 965.e3
[2] Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
Davies, Neil M.
Holmes, Michael V.
Smith, George Davey
[J]. BMJ-BRITISH MEDICAL JOURNAL, 2018, 362
[3] Associations of Intrapancreatic Fat Deposition With Incident Diseases of the Exocrine and Endocrine Pancreas: A UK Biobank Prospective Cohort Study
Dong, Xiaowu
Zhu, Qingtian
Yuan, Chenchen
Wang, Yaodong
Ma, Xiaojie
Shi, Xiaolei
Chen, Weiwei
Dong, Zhao
Chen, Lin
Shen, Qinhao
Xu, Hongwei
Ding, Yanbing
Gong, Weijuan
Xiao, Weiming
Wang, Shengfeng
Li, Weiqin
Lu, Guotao
[J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2024, 119 (06) : 1158 - 1166
[4] Impact of fatty pancreas and lifestyle on the development of subclinical chronic pancreatitis in healthy people undergoing a medical checkup
Fujii, Makoto
Ohno, Yuko
Yamada, Makoto
Kamada, Yoshihiro
Miyoshi, Eiji
[J]. ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 2019, 24 (01)
[5] FinnGen provides genetic insights from a well-phenotyped isolated population
Kurki, Mitja, I
Karjalainen, Juha
Palta, Priit
Sipila, Timo P.
Kristiansson, Kati
Donner, Kati M.
Reeve, Mary P.
Laivuori, Hannele
Aavikko, Mervi
Kaunisto, Mari A.
Loukola, Anu
Lahtela, Elisa
Mattsson, Hannele
Laiho, Paivi
Parolo, Pietro Della Briotta
Lehisto, Arto A.
Kanai, Masahiro
Mars, Nina
Ramo, Joel
Kiiskinen, Tuomo
Heyne, Henrike O.
Veerapen, Kumar
Rueger, Sina
Lemmela, Susanna
Zhou, Wei
Ruotsalainen, Sanni
Parn, Kalle
Hiekkalinna, Tero
Koskelainen, Sami
Paajanen, Teemu
Llorens, Vincent
Gracia-Tabuenca, Javier
Siirtola, Harri
Reis, Kadri
Elnahas, Abdelrahman G.
Sun, Benjamin
Foley, Christopher N.
Aalto-Setala, Katriina
Alasoo, Kaur
Arvas, Mikko
Auro, Kirsi
Biswas, Shameek
Bizaki-Vallaskangas, Argyro
Carpen, Olli
Chen, Chia-Yen
Dada, Oluwaseun A.
Ding, Zhihao
Ehm, Margaret G.
Eklund, Kari
Farkkila, Martti
[J]. NATURE, 2023, 613 (7944) : 508 - +
[6] Association of Genetic Variants Related to Serum Calcium Levels With Coronary Artery Disease and Myocardial Infarction
Larsson, Susanna C.
Burgess, Stephen
Michaelsson, Karl
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2017, 318 (04): : 371 - 380
[7] Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Liu, Mengzhen
Jiang, Yu
Wedow, Robbee
Li, Yue
Brazel, David M.
Chen, Fang
Datta, Gargi
Davila-Velderrain, Jose
McGuire, Daniel
Tian, Chao
Zhan, Xiaowei
Choquet, Helene
Docherty, Anna R.
Faul, Jessica D.
Foerster, Johanna R.
Fritsche, Lars G.
Gabrielsen, Maiken Elvestad
Gordon, Scott D.
Haessler, Jeffrey
Hottenga, Jouke-Jan
Huang, Hongyan
Jang, Seon-Kyeong
Jansen, Philip R.
Ling, Yueh
Magi, Reedik
Matoba, Nana
McMahon, George
Mulas, Antonella
Orru, Valeria
Palviainen, Teemu
Pandit, Anita
Reginsson, Gunnar W.
Skogholt, Anne Heidi
Smith, Jennifer A.
Taylor, Amy E.
Turman, Constance
Willemsen, Gonneke
Young, Hannah
Young, Kendra A.
Zajac, Gregory J. M.
Zhao, Wei
Zhou, Wei
Bjornsdottir, Gyda
Boardman, Jason D.
Boehnke, Michael
Boomsma, Dorret I.
Chen, Chu
Cucca, Francesco
Davies, Gareth E.
Eaton, Charles B.
[J]. NATURE GENETICS, 2019, 51 (02) : 237 - +
[8] Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning
Liu, Yi
Basty, Nicolas
Whitcher, Brandon
Bell, Jimmy D.
Sorokin, Elena P.
van Bruggen, Nick
Thomas, E. Louise
Cule, Madeleine
[J]. ELIFE, 2021, 10
[9] Computationally efficient whole-genome regression for quantitative and binary traits
Mbatchou, Joelle
Barnard, Leland
Backman, Joshua
Marcketta, Anthony
Kosmicki, Jack A.
Ziyatdinov, Andrey
Benner, Christian
O'Dushlaine, Colm
Barber, Mathew
Boutkov, Boris
Habegger, Lukas
Ferreira, Manuel
Baras, Aris
Reid, Jeffrey
Abecasis, Goncalo
Maxwell, Evan
Marchini, Jonathan
[J]. NATURE GENETICS, 2021, 53 (07) : 1097 - +
[10] Acute Pancreatitis: A Review
Mederos, Michael A.
Reber, Howard A.
Girgis, Mark D.
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (04): : 382 - 390

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