This study investigates the anti-aging effects of various concentrations of blueberry anthocyanins (BA) on the lifespan and health-related phenotypes of Caenorhabditis elegans. Blueberry anthocyanins were administered at concentrations of 50.0 mu g/mL, 200.0 mu g/mL, and 500.0 mu g/mL, and their effects on nematode lifespan, locomotion, pharyngeal pumping rate, and the accumulation of lipofuscin and reactive oxygen species (ROS) were examined. Transcriptomic analysis was conducted to explore the regulatory effects of BA on anti-aging molecular pathways and key genes in C. elegans. Results showed a significant, dose-dependent extension of lifespan, improvement in locomotion and pharyngeal pumping rate, and reduction in lipofuscin and ROS accumulation. Transcriptomic analysis revealed that BA activated anti-aging pathways such as FOXO, IIS, and PI3K/Akt, upregulating critical genes like daf-16. These findings highlight the potential of blueberry anthocyanins as promising anti-aging agents through multiple physiological and molecular mechanisms.
机构:
Beckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USABeckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USA
Adams, Lynn S.
Phung, Sheryl
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机构:
Beckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USABeckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USA
Phung, Sheryl
Yee, Natalie
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h-index: 0
机构:
Beckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USABeckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USA
Yee, Natalie
Seeram, Navindra P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rhode Isl, Bioact Bot Res Lab, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USABeckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USA
Seeram, Navindra P.
Li, Liya
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rhode Isl, Bioact Bot Res Lab, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USABeckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USA
Li, Liya
Chen, Shiuan
论文数: 0引用数: 0
h-index: 0
机构:
Beckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USABeckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USA
机构:
Univ Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, England
Univ Manchester, Fac Sci & Engn, Dept Math, Manchester M13 9PL, EnglandUniv Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, England
Gavrilova, Anna
Bostro, Astrid
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h-index: 0
机构:
Univ Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, EnglandUniv Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, England
Bostro, Astrid
Korabel, Nickolay
论文数: 0引用数: 0
h-index: 0
机构:
Univ Manchester, Fac Sci & Engn, Dept Math, Manchester M13 9PL, EnglandUniv Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, England
Korabel, Nickolay
Fedotov, Sergei
论文数: 0引用数: 0
h-index: 0
机构:
Univ Manchester, Fac Sci & Engn, Dept Math, Manchester M13 9PL, EnglandUniv Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, England
Fedotov, Sergei
Poulin, Gino B.
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h-index: 0
机构:
Univ Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, EnglandUniv Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, England
Poulin, Gino B.
Allan, Victoria J.
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h-index: 0
机构:
Univ Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, EnglandUniv Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, England
机构:
Univ Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, SpainUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain
Gonzalez-Paramas, Ana M.
Brighenti, Virginia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Dept Life Sci, Via G Campi 103, I-41125 Modena, ItalyUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain
Brighenti, Virginia
Bertoni, Laura
论文数: 0引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Dept Life Sci, Via G Campi 103, I-41125 Modena, ItalyUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain
Bertoni, Laura
Marcelloni, Laura
论文数: 0引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Dept Life Sci, Via G Campi 103, I-41125 Modena, ItalyUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain
Marcelloni, Laura
Ayuda-Duran, Begona
论文数: 0引用数: 0
h-index: 0
机构:
Univ Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, SpainUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain
Ayuda-Duran, Begona
Gonzalez-Manzano, Susana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, SpainUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain
Gonzalez-Manzano, Susana
Pellati, Federica
论文数: 0引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Dept Life Sci, Via G Campi 103, I-41125 Modena, ItalyUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain
Pellati, Federica
Santos-Buelga, Celestino
论文数: 0引用数: 0
h-index: 0
机构:
Univ Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, SpainUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain
机构:
Beckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USABeckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USA
Adams, Lynn S.
Phung, Sheryl
论文数: 0引用数: 0
h-index: 0
机构:
Beckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USABeckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USA
Phung, Sheryl
Yee, Natalie
论文数: 0引用数: 0
h-index: 0
机构:
Beckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USABeckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USA
Yee, Natalie
Seeram, Navindra P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rhode Isl, Bioact Bot Res Lab, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USABeckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USA
Seeram, Navindra P.
Li, Liya
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rhode Isl, Bioact Bot Res Lab, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USABeckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USA
Li, Liya
Chen, Shiuan
论文数: 0引用数: 0
h-index: 0
机构:
Beckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USABeckman Res Inst City Hope, Div Tumor Cell Biol, Duarte, CA 91010 USA
机构:
Univ Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, England
Univ Manchester, Fac Sci & Engn, Dept Math, Manchester M13 9PL, EnglandUniv Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, England
Gavrilova, Anna
Bostro, Astrid
论文数: 0引用数: 0
h-index: 0
机构:
Univ Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, EnglandUniv Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, England
Bostro, Astrid
Korabel, Nickolay
论文数: 0引用数: 0
h-index: 0
机构:
Univ Manchester, Fac Sci & Engn, Dept Math, Manchester M13 9PL, EnglandUniv Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, England
Korabel, Nickolay
Fedotov, Sergei
论文数: 0引用数: 0
h-index: 0
机构:
Univ Manchester, Fac Sci & Engn, Dept Math, Manchester M13 9PL, EnglandUniv Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, England
Fedotov, Sergei
Poulin, Gino B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, EnglandUniv Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, England
Poulin, Gino B.
Allan, Victoria J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, EnglandUniv Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Michael Smith Bldg,Rumford St, Manchester M13 9PT, England
机构:
Univ Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, SpainUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain
Gonzalez-Paramas, Ana M.
Brighenti, Virginia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Dept Life Sci, Via G Campi 103, I-41125 Modena, ItalyUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain
Brighenti, Virginia
Bertoni, Laura
论文数: 0引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Dept Life Sci, Via G Campi 103, I-41125 Modena, ItalyUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain
Bertoni, Laura
Marcelloni, Laura
论文数: 0引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Dept Life Sci, Via G Campi 103, I-41125 Modena, ItalyUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain
Marcelloni, Laura
Ayuda-Duran, Begona
论文数: 0引用数: 0
h-index: 0
机构:
Univ Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, SpainUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain
Ayuda-Duran, Begona
Gonzalez-Manzano, Susana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, SpainUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain
Gonzalez-Manzano, Susana
Pellati, Federica
论文数: 0引用数: 0
h-index: 0
机构:
Univ Modena & Reggio Emilia, Dept Life Sci, Via G Campi 103, I-41125 Modena, ItalyUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain
Pellati, Federica
Santos-Buelga, Celestino
论文数: 0引用数: 0
h-index: 0
机构:
Univ Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, SpainUniv Salamanca, Fac Farm, Unidad Nutr & Bromatol, Grp Invest Polifenoles, Campus Miguel de Unamuno, Salamanca 37007, Spain