Biomarkers for Health Functional Foods in Metabolic Dysfunction-Associated Steatotic Liver Disorder (MASLD) Prevention: An Integrative Analysis of Network Pharmacology, Gut Microbiota, and Multi-Omics

被引:8
|
作者
Yuan, Heng [1 ]
Jung, Eun-Soo [2 ,3 ,4 ]
Chae, Soo-Wan [2 ,3 ,4 ]
Jung, Su-Jin [2 ,3 ,4 ]
Daily, James W. [5 ]
Park, Sunmin [1 ,6 ]
机构
[1] Hoseo Univ, Dept Bioconvergence, Asan 31499, South Korea
[2] Jeonbuk Natl Univ Hosp, Biomed Res Inst, Clin Trial Ctr Funct Foods, Jeonju 54907, South Korea
[3] Jeonbuk Natl Univ Hosp, Biomed Res Inst, Clin Trial Ctr K FOOD Microbiome, Jeonju 54907, South Korea
[4] Jeonbuk Natl Univ, Res Inst Clin Med, Jeonju 54907, South Korea
[5] Daily Mfg Inc, Dept R&D, Rockwell, NC 28138 USA
[6] Hoseo Univ, Obes Diabet Res Ctr, Dept Food & Nutr, 20 Hoseoro79 Bungil, Asan 31499, South Korea
关键词
metabolic dysfunction-associated steatotic liver disease; HFFs; gut microbiota; omics approach; HEPATIC STEATOSIS; NONCODING RNAS; DISEASE; PATHOGENESIS; CELLS; INFLAMMATION; CROSSTALK; NAFLD; NASH;
D O I
10.3390/nu16183061
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Metabolic dysfunction-associated steatotic liver disorder (MASLD) is increasingly prevalent globally, highlighting the need for preventive strategies and early interventions. This comprehensive review explores the potential of health functional foods (HFFs) to maintain healthy liver function and prevent MASLD through an integrative analysis of network pharmacology, gut microbiota, and multi-omics approaches. We first examined the biomarkers associated with MASLD, emphasizing the complex interplay of genetic, environmental, and lifestyle factors. We then applied network pharmacology to identify food components with potential beneficial effects on liver health and metabolic function, elucidating their action mechanisms. This review identifies and evaluates strategies for halting or reversing the development of steatotic liver disease in the early stages, as well as biomarkers that can evaluate the success or failure of such strategies. The crucial role of the gut microbiota and its metabolites for MASLD prevention and metabolic homeostasis is discussed. We also cover state-of-the-art omics approaches, including transcriptomics, metabolomics, and integrated multi-omics analyses, in research on preventing MASLD. These advanced technologies provide deeper insights into physiological mechanisms and potential biomarkers for HFF development. The review concludes by proposing an integrated approach for developing HFFs targeting MASLD prevention, considering the Korean regulatory framework. We outline future research directions that bridge the gap between basic science and practical applications in health functional food development. This narrative review provides a foundation for researchers and food industry professionals interested in developing HFFs to support liver health. Emphasis is placed on maintaining metabolic balance and focusing on prevention and early-stage intervention strategies.
引用
收藏
页数:22
相关论文
共 26 条
  • [1] Gut microbiota and metabolic biomarkers in metabolic dysfunction-associated steatotic liver disease
    Long, Qichen
    Luo, Fengming
    Li, Binghui
    Li, Ziyang
    Guo, Zhe
    Chen, Zhiyang
    Wu, Weimin
    Hu, Min
    HEPATOLOGY COMMUNICATIONS, 2024, 8 (03)
  • [2] Gut Microbiota and Metabolic Dysfunction-Associated Steatotic Liver Disease
    Scarpellini, Emidio
    Scarcella, Marialaura
    Tack, Jan F.
    Scarlata, Giuseppe Guido Maria
    Zanetti, Michela
    Abenavoli, Ludovico
    ANTIOXIDANTS, 2024, 13 (11)
  • [3] Dietary Influences on Gut Microbiota and Their Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
    Hamamah, Sevag
    Iatcu, Oana C.
    Covasa, Mihai
    NUTRIENTS, 2025, 17 (01)
  • [4] Gut microbiota-NLRP3 inflammasome crosstalk in metabolic dysfunction-associated steatotic liver disease
    Yu, Tingting
    Luo, Lei
    Xue, Juan
    Tang, Wenqian
    Wu, Xiaojie
    Yang, Fan
    CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2024, 48 (08)
  • [5] Effects of Selected Food Additives on the Gut Microbiome and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
    Jarmakiewicz-Czaja, Sara
    Sokal-Dembowska, Aneta
    Filip, Rafal
    MEDICINA-LITHUANIA, 2025, 61 (02):
  • [6] NAD metabolic therapy in metabolic dysfunction-associated steatotic liver disease: Possible roles of gut microbiota
    Lu, Xinyi
    Yang, Rui
    Chen, Yu
    Chen, Daozhen
    ISCIENCE, 2024, 27 (03)
  • [7] Relationship between sarcopenia and metabolic dysfunction-associated steatotic liver disease (MASLD): A systematic review and meta-analysis
    Malik, Adnan
    Javaid, Sadia
    Malik, Muhammad Imran
    Qureshi, Shahbaz
    ANNALS OF HEPATOLOGY, 2024, 29 (06)
  • [8] Bioinformatic analysis of molecular expression patterns during the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD)
    Lan, Yuanfeng
    Song, Ran
    Feng, Duiping
    He, Junqi
    SCIENTIFIC REPORTS, 2025, 15 (01):
  • [9] Characteristics of gut microbiota and metabolic phenotype in patients with major depressive disorder based on multi-omics analysis
    Zu, Xianpeng
    Xin, Jiayun
    Xie, Haisheng
    Xu, Xike
    Shen, Yunheng
    Wang, Jinxin
    Tian, Saisai
    Wen, Yukun
    Li, Hongxia
    Yang, Jishun
    Fang, Yiqun
    JOURNAL OF AFFECTIVE DISORDERS, 2024, 344 : 563 - 576
  • [10] Non-invasive Scores and Serum Biomarkers for Fatty Liver in the Era of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD): A Comprehensive Review From NAFLD to MAFLD and MASLD
    Abdelhameed, Farah
    Kite, Chris
    Lagojda, Lukasz
    Dallaway, Alexander
    Chatha, Kamaljit Kaur
    Chaggar, Surinderjeet S.
    Dalamaga, Maria
    Kassi, Eva
    Kyrou, Ioannis
    Randeva, Harpal S.
    CURRENT OBESITY REPORTS, 2024, 13 (03): : 510 - 531