Utilization of Inhaled Antibiotics in Pediatric Non-Cystic Fibrosis Bronchiectasis: A Comprehensive Review

被引:0
|
作者
Tsouprou, Maria [1 ,2 ]
Koumpagioti, Despoina [3 ]
Botsa, Evanthia [2 ]
Douros, Konstantinos [1 ]
Moriki, Dafni [1 ]
机构
[1] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Sch Med, Dept Pediat 3,Pediatr Allergy & Resp Unit, Athens 12462, Greece
[2] Agia Sofia Hosp, Dept Pediat, Pediat Clin 1, Athens 11527, Greece
[3] Childrens Hosp Panagiotis & Aglaia Kyriakou, Athens 11527, Greece
来源
ANTIBIOTICS-BASEL | 2025年 / 14卷 / 02期
关键词
<italic>Pseudomonas aeruginosa</italic>; inhaled antibiotics; non-CF bronchiectasis; children; colistin; tobramycin; HIGH-RESOLUTION CT; PROTRACTED BACTERIAL BRONCHITIS; SUPPURATIVE LUNG-DISEASE; DOUBLE-BLIND; BRONCHOARTERIAL RATIO; NEBULIZED GENTAMICIN; INDIGENOUS CHILDREN; RESPIRATORY-TRACT; TOBRAMYCIN; CF;
D O I
10.3390/antibiotics14020165
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The lack of available treatments in pediatric non-cystic fibrosis (non-CF) bronchiectasis is a major concern, especially in the context of the increasing disease burden due to better detection rates with advanced imaging techniques. Recurrent infections in these patients are the main cause of deterioration, leading to impaired lung function and increasing the risk of morbidity and mortality. Since pediatric non-CF bronchiectasis with early recognition and appropriate treatment can be reversible, optimal management is an issue of growing significance. The use of inhaled antibiotics as a treatment option, although a standard of care for CF patients, has been poorly studied in patients with non-CF bronchiectasis, especially in children. In this review, we present the current data on the potential use of inhaled antibiotics in the treatment of non-CF bronchiectasis and assess their safety and efficacy profile, focusing mainly on children. We conclude that inhaled antibiotics as an adjuvant maintenance treatment option could be tried in a subgroup of patients with frequent exacerbations and recent or chronic Pseudomonas aeruginosa infection as they appear to have beneficial effects on exacerbation rate and bacterial load with minimal safety concerns. However, the level of evidence in children is extremely low; therefore, further research is needed on the validity of this recommendation.
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页数:22
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