DNA/RNA Origami Based on Different Scaffolds and Their Biomedical Applications

被引：0

作者：

Fan, Jing ^{[1
,2
]}

Yang, Changping ^{[1
,2
]}

Zhu, Hanyin ^{[2
,3
]}

Wang, Hong ^{[2
,3
]}

Li, Xintong ^{[2
,3
]}

Liu, Jianbing ^{[2
,3
]}

Ding, Baoquan ^{[1
,2
,3
]}

机构：

[1] Zhengzhou Univ, Henan Inst Adv Technol, Sch Mat Sci & Engn, Zhengzhou 450001, Peoples R China

[2] Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarch Fabricat, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2025年 / 11卷 / 04期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

nucleic acid biomaterials; self-assembly; DNAorigami; RNA origami; biomedical applications; ROLLING CIRCLE AMPLIFICATION; DNA ORIGAMI; STRANDED-DNA; BRANCHED DNA; FOLDING DNA; NANOSTRUCTURES; RNA; NANOPARTICLES; TRANSPORT; MOLECULE;

D O I：

10.1021/acsbiomaterials.5c00154

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Nucleic acids, including DNA and RNA, have been used extensively as building blocks to construct sophisticated nanostructures through complementary base pairing with predetermined shapes and sizes. With remarkable biocompatibility, spatial addressability, and structural programmability, self-assembled nucleic acid biomaterials have found widespread applications in various biomedical researches, including drug delivery, bioimaging, or disease diagnosis. Notably, as one of the representative nanostructures, DNA origami has drawn much attention. In this review, we summarize the latest developments in DNA/RNA origami design based on single-stranded DNA (ssDNA), double-stranded DNA (dsDNA), and single-stranded RNA (ssRNA) scaffolds for a range of biomedical applications, including drug delivery, gene regulation, immunomodulation, and receptor recognition. Additionally, the challenges and future opportunities of DNA/RNA origami in biomedical applications will be discussed.

引用

页码：2080 / 2095

页数：16

共 168 条

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