Body Mass Index: An Unreliable Adiposity Indicator for Predicting Outcomes of Liver Transplantation Due to Hepatocellular Carcinoma

被引:0
作者
Czarnecka, Kinga [1 ]
Czarnecka, Paulina [1 ]
Tronina, Olga [1 ]
Baczkowska, Teresa [1 ]
Durlik, Magdalena [1 ]
机构
[1] Med Univ Warsaw, Dept Transplant Med Immunol Nephrol & Internal Dis, 59 Nowogrodzka St, PL-02006 Warsaw, Poland
来源
GASTROINTESTINAL DISORDERS | 2024年 / 6卷 / 03期
关键词
hepatocellular carcinoma; liver transplantation; obesity; body mass index; hepatocellular carcinoma recurrence; VISCERAL ADIPOSITY; HEPATIC RESECTION; RECURRENCE; OBESITY; IMPACT; RISK; MODEL;
D O I
10.3390/gidisord6030040
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Obesity is a well-documented risk factor for the development of hepatocellular carcinoma (HCC) in the general population. The applicability of these findings to liver recipients is uncertain, and the results of available data have not been unanimous. The objective of the current study was to investigate the impact of the pre-operative body mass index (BMI) on oncological outcomes of liver transplantation due to HCC. Methods: This observational retrospective study enrolled all patients with histologically confirmed HCC who underwent liver transplantation from a deceased donor in our centre between 2008 and 2018. Results: Overall, 83 patients were enrolled and were subsequently stratified according to their pre-operative BMI into three groups: patients with normal body weight (n = 53), patients with overweight (n = 23), patients with obesity (n = 7). Overall tumour recurrence was 12%. BMI failed to predict the 5-year recurrence-free survival (p = 0.55), risk of tumour recurrence (p = 0.314) and overall 5-year survival (p = 0.19) in liver recipients. Conclusions: BMI was proven to be an unreliable surrogate measure of obesity for predicting oncological outcomes among liver recipients. Other obesity indices should be referenced to assess cancer-related prognosis more accurately in these groups of patients.
引用
收藏
页码:607 / 621
页数:15
相关论文
共 51 条
  • [21] The Warsaw Proposal for the Use of Extended Selection Criteria in Liver Transplantation for Hepatocellular Cancer
    Grat, Michal
    Wronka, Karolina M.
    Stypulkowski, Jan
    Bik, Emil
    Krasnodebski, Maciej
    Masior, Lukasz
    Lewandowski, Zbigniew
    Grat, Karolina
    Patkowski, Waldemar
    Krawczyk, Marek
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2017, 24 (02) : 526 - 534
  • [22] Obesity is Independently Associated With Increased Risk of Hepatocellular Cancer-related Mortality A Systematic Review and Meta-Analysis
    Gupta, Arjun
    Das, Avash
    Majumder, Kaustav
    Arora, Nivedita
    Mayo, Helen G.
    Singh, Preet P.
    Beg, Muhammad S.
    Singh, Siddharth
    [J]. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2018, 41 (09): : 874 - 881
  • [23] Is it Time to Abandon the Milan Criteria? Results of a Bicoastal US Collaboration to Redefine Hepatocellular Carcinoma Liver Transplantation Selection Policies
    Halazun, Karim J.
    Tabrizian, Parissa
    Najjar, Marc
    Florman, Sander
    Schwartz, Myron
    Michelassi, Fabrizio
    Samstein, Benjamin
    Brown, Robert S., Jr.
    Emond, Jean C.
    Busuttil, Ronald W.
    Agopian, Vatche G.
    [J]. ANNALS OF SURGERY, 2018, 268 (04) : 690 - 699
  • [24] Recurrence After Liver Transplantation for Hepatocellular Carcinoma A New MORAL to the Story
    Halazun, Karim J.
    Najjar, Marc
    Abdelmessih, Rita M.
    Samstein, Benjamin
    Griesemer, Adam D.
    Guarrera, James V.
    Kato, Tomoaki
    Verna, Elizabeth C.
    Emond, Jean C.
    Brown, Robert S., Jr.
    [J]. ANNALS OF SURGERY, 2017, 265 (03) : 557 - 564
  • [25] Preoperative Visceral Adiposity and Muscularity Predict Poor Outcomes after Hepatectomy for Hepatocellular Carcinoma
    Hamaguchi, Yuhei
    Kaido, Toshimi
    Okumura, Shinya
    Kobayashi, Atsushi
    Shirai, Hisaya
    Yao, Siyuan
    Yagi, Shintaro
    Kamo, Naoko
    Seo, Satoru
    Taura, Kojiro
    Okajima, Hideaki
    Uemoto, Shinji
    [J]. LIVER CANCER, 2019, 8 (02) : 92 - 109
  • [26] Effect of Body Composition on Outcomes after Hepatic Resection for Hepatocellular Carcinoma
    Itoh, Shinji
    Shirabe, Ken
    Matsumoto, Yoshihiro
    Yoshiya, Shohei
    Muto, Jun
    Harimoto, Norifumi
    Yamashita, Yo-ichi
    Ikegami, Toru
    Yoshizumi, Tomoharu
    Nishie, Akihiro
    Maehara, Yoshihiko
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2014, 21 (09) : 3063 - 3068
  • [27] Overweight or Obesity is an Unfavorable Long-Term Prognostic Factor for Patients who Underwent Gastrectomy for Stage II/III Gastric Cancer
    Kambara, Yuichi
    Yuasa, Norihiro
    Takeuchi, Eiji
    Miyake, Hideo
    Nagai, Hidemasa
    Yoshioka, Yuichiro
    Okuno, Masataka
    Miyata, Kanji
    [J]. WORLD JOURNAL OF SURGERY, 2019, 43 (07) : 1766 - 1776
  • [28] Obesity and the Risk of Gastrointestinal Cancers
    Karczewski, Jacek
    Begier-Krasinska, Beata
    Staszewski, Rafal
    Poplawska, Edyta
    Gulczynska-Elhadi, Katarzyna
    Dobrowolska, Agnieszka
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2019, 64 (10) : 2740 - 2749
  • [29] Kim JH, 2018, J HEPATOL, V69, P1066, DOI [10.1016/j.jhep.2018.07.018, 10.1016/s0168-8278(18)31215-7]
  • [30] Impact of Sarcopenic Obesity on Outcomes in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma
    Kobayashi, Atsushi
    Kaido, Toshimi
    Hamaguchi, Yuhei
    Okumura, Shinya
    Shirai, Hisaya
    Yao, Siyuan
    Kamo, Naoko
    Yagi, Shintaro
    Taura, Kojiro
    Okajima, Hideaki
    Uemoto, Shinji
    [J]. ANNALS OF SURGERY, 2019, 269 (05) : 924 - 931