hepatocellular carcinoma;
liver transplantation;
obesity;
body mass index;
hepatocellular carcinoma recurrence;
VISCERAL ADIPOSITY;
HEPATIC RESECTION;
RECURRENCE;
OBESITY;
IMPACT;
RISK;
MODEL;
D O I:
10.3390/gidisord6030040
中图分类号:
R57 [消化系及腹部疾病];
学科分类号:
摘要:
Obesity is a well-documented risk factor for the development of hepatocellular carcinoma (HCC) in the general population. The applicability of these findings to liver recipients is uncertain, and the results of available data have not been unanimous. The objective of the current study was to investigate the impact of the pre-operative body mass index (BMI) on oncological outcomes of liver transplantation due to HCC. Methods: This observational retrospective study enrolled all patients with histologically confirmed HCC who underwent liver transplantation from a deceased donor in our centre between 2008 and 2018. Results: Overall, 83 patients were enrolled and were subsequently stratified according to their pre-operative BMI into three groups: patients with normal body weight (n = 53), patients with overweight (n = 23), patients with obesity (n = 7). Overall tumour recurrence was 12%. BMI failed to predict the 5-year recurrence-free survival (p = 0.55), risk of tumour recurrence (p = 0.314) and overall 5-year survival (p = 0.19) in liver recipients. Conclusions: BMI was proven to be an unreliable surrogate measure of obesity for predicting oncological outcomes among liver recipients. Other obesity indices should be referenced to assess cancer-related prognosis more accurately in these groups of patients.
机构:
Univ London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, EnglandUniv London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England
Bhaskaran, Krishnan
;
Douglas, Ian
论文数: 0引用数: 0
h-index: 0
机构:
Univ London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, EnglandUniv London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England
Douglas, Ian
;
Forbes, Harriet
论文数: 0引用数: 0
h-index: 0
机构:
Univ London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, EnglandUniv London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England
Forbes, Harriet
;
dos-Santos-Silva, Isabel
论文数: 0引用数: 0
h-index: 0
机构:
Univ London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, EnglandUniv London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England
dos-Santos-Silva, Isabel
;
Leon, David A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, EnglandUniv London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England
Leon, David A.
;
Smeeth, Liam
论文数: 0引用数: 0
h-index: 0
机构:
Univ London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England
Farr Inst Hlth Informat Res, London, EnglandUniv London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England
机构:
Univ Hlth Network, Ajmera Transplant Program, Toronto, ON, Canada
Univ Hlth Network, Toronto Gen Hosp Res Inst, Toronto, ON, Canada
Univ Toronto, Inst Med Sci, Toronto, ON, Canada
Univ Toronto, Dept Med, Div Gastroenterol & Hepatol, Toronto, ON, CanadaUniv Hlth Network, Ajmera Transplant Program, Toronto, ON, Canada
Bhat, Mamatha
;
Rabindranath, Madhumitha
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hlth Network, Ajmera Transplant Program, Toronto, ON, Canada
Univ Hlth Network, Toronto Gen Hosp Res Inst, Toronto, ON, Canada
Univ Toronto, Inst Med Sci, Toronto, ON, CanadaUniv Hlth Network, Ajmera Transplant Program, Toronto, ON, Canada
Rabindranath, Madhumitha
;
Chara, Beatriz Sordi
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USAUniv Hlth Network, Ajmera Transplant Program, Toronto, ON, Canada
Chara, Beatriz Sordi
;
Simonetto, Douglas A.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USAUniv Hlth Network, Ajmera Transplant Program, Toronto, ON, Canada
机构:
Dumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Dumont UCLA Liver Canc Ctr, Dept Surg, Los Angeles, CA USA
Univ Chicago, Dept Surg, Sect Transplantat, 5841 S Maryland Ave, Chicago, IL 60637 USADumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Bodzin, Adam S.
;
Lunsford, Keri E.
论文数: 0引用数: 0
h-index: 0
机构:
Dumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Dumont UCLA Liver Canc Ctr, Dept Surg, Los Angeles, CA USA
Houston Methodist Hosp, Dept Surg, JC Walter Jr Ctr Transplantat, Houston, TX USADumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Lunsford, Keri E.
;
Markovic, Daniela
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Biomath, Los Angeles, CA 90095 USADumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Markovic, Daniela
;
Harlander-Locke, Michael P.
论文数: 0引用数: 0
h-index: 0
机构:
Dumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Dumont UCLA Liver Canc Ctr, Dept Surg, Los Angeles, CA USADumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Harlander-Locke, Michael P.
;
Busuttil, Ronald W.
论文数: 0引用数: 0
h-index: 0
机构:
Dumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Dumont UCLA Liver Canc Ctr, Dept Surg, Los Angeles, CA USADumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Busuttil, Ronald W.
;
Agopian, Vatche G.
论文数: 0引用数: 0
h-index: 0
机构:
Dumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Dumont UCLA Liver Canc Ctr, Dept Surg, Los Angeles, CA USADumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
机构:
Canc Surveillance Branch, Int Agcy Res Canc, Lyon, France
Int Agcy Res Canc IARC, Canc Surveillance Branch, 25 Ave Tony Garnier, F-69366 Lyon 07, FranceCanc Surveillance Branch, Int Agcy Res Canc, Lyon, France
Bray, Freddie
;
Laversanne, Mathieu
论文数: 0引用数: 0
h-index: 0
机构:
Canc Surveillance Branch, Int Agcy Res Canc, Lyon, FranceCanc Surveillance Branch, Int Agcy Res Canc, Lyon, France
Laversanne, Mathieu
;
Sung, Hyuna
论文数: 0引用数: 0
h-index: 0
机构:
Amer Canc Soc, Surveillance & Hlth Equ Sci, Atlanta, GA USACanc Surveillance Branch, Int Agcy Res Canc, Lyon, France
Sung, Hyuna
;
Ferlay, Jacques
论文数: 0引用数: 0
h-index: 0
机构:
Canc Surveillance Branch, Int Agcy Res Canc, Lyon, FranceCanc Surveillance Branch, Int Agcy Res Canc, Lyon, France
Ferlay, Jacques
;
Siegel, Rebecca L.
论文数: 0引用数: 0
h-index: 0
机构:
Amer Canc Soc, Surveillance & Hlth Equ Sci, Atlanta, GA USACanc Surveillance Branch, Int Agcy Res Canc, Lyon, France
Siegel, Rebecca L.
;
Soerjomataram, Isabelle
论文数: 0引用数: 0
h-index: 0
机构:
Canc Surveillance Branch, Int Agcy Res Canc, Lyon, FranceCanc Surveillance Branch, Int Agcy Res Canc, Lyon, France
Soerjomataram, Isabelle
;
Jemal, Ahmedin
论文数: 0引用数: 0
h-index: 0
机构:
Amer Canc Soc, Surveillance & Hlth Equ Sci, Atlanta, GA USACanc Surveillance Branch, Int Agcy Res Canc, Lyon, France
机构:
Henri Mondor Univ Hosp, AP HP, Dept Pathol, Creteil, France
INSERM, U955, F-94010 Creteil, France
Univ Paris Est Creteil, INSERM, IMRB, F-94010 Creteil, FranceHenri Mondor Univ Hosp, AP HP, Dept Pathol, Creteil, France
Calderaro, Julien
;
Seraphin, Tobias Paul
论文数: 0引用数: 0
h-index: 0
机构:
Heinrich Heine Univ Duesseldorf, Med Fac, Univ Hosp Duesseldorf, Dept Gastroenterol Hepatol & Infect Dis, Dusseldorf, GermanyHenri Mondor Univ Hosp, AP HP, Dept Pathol, Creteil, France
Seraphin, Tobias Paul
;
论文数: 引用数:
h-index:
机构:
Luedde, Tom
;
Simon, Tracey G.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Liver Ctr, Div Gastroenterol, 55 Fruit St,Wang 5th Floor, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit CTEU, Boston, MA 02114 USAHenri Mondor Univ Hosp, AP HP, Dept Pathol, Creteil, France
机构:
Hop Henri Mondor, AP HP, Unit Digest Hepatopancreatobiliary Surg & Liver T, F-94010 Creteil, France
Hop Henri Mondor, INSERM, U4394, MACBEth, F-94010 Creteil, France
Univ Naples Federico II, Dept Adv Biomed Sci, I-80138 Naples, ItalyHop Henri Mondor, AP HP, Unit Digest Hepatopancreatobiliary Surg & Liver T, F-94010 Creteil, France
de'Angelis, Nicola
;
Landi, Filippo
论文数: 0引用数: 0
h-index: 0
机构:
Hop Henri Mondor, AP HP, Unit Digest Hepatopancreatobiliary Surg & Liver T, F-94010 Creteil, FranceHop Henri Mondor, AP HP, Unit Digest Hepatopancreatobiliary Surg & Liver T, F-94010 Creteil, France
Landi, Filippo
;
论文数: 引用数:
h-index:
机构:
Carra, Maria Clotilde
;
Azoulay, Daniel
论文数: 0引用数: 0
h-index: 0
机构:
Hop Henri Mondor, AP HP, Unit Digest Hepatopancreatobiliary Surg & Liver T, F-94010 Creteil, France
Hop Henri Mondor, INSERM, U955, IMRB, F-94010 Creteil, FranceHop Henri Mondor, AP HP, Unit Digest Hepatopancreatobiliary Surg & Liver T, F-94010 Creteil, France
机构:
Univ London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, EnglandUniv London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England
Bhaskaran, Krishnan
;
Douglas, Ian
论文数: 0引用数: 0
h-index: 0
机构:
Univ London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, EnglandUniv London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England
Douglas, Ian
;
Forbes, Harriet
论文数: 0引用数: 0
h-index: 0
机构:
Univ London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, EnglandUniv London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England
Forbes, Harriet
;
dos-Santos-Silva, Isabel
论文数: 0引用数: 0
h-index: 0
机构:
Univ London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, EnglandUniv London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England
dos-Santos-Silva, Isabel
;
Leon, David A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, EnglandUniv London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England
Leon, David A.
;
Smeeth, Liam
论文数: 0引用数: 0
h-index: 0
机构:
Univ London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England
Farr Inst Hlth Informat Res, London, EnglandUniv London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England
机构:
Univ Hlth Network, Ajmera Transplant Program, Toronto, ON, Canada
Univ Hlth Network, Toronto Gen Hosp Res Inst, Toronto, ON, Canada
Univ Toronto, Inst Med Sci, Toronto, ON, Canada
Univ Toronto, Dept Med, Div Gastroenterol & Hepatol, Toronto, ON, CanadaUniv Hlth Network, Ajmera Transplant Program, Toronto, ON, Canada
Bhat, Mamatha
;
Rabindranath, Madhumitha
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hlth Network, Ajmera Transplant Program, Toronto, ON, Canada
Univ Hlth Network, Toronto Gen Hosp Res Inst, Toronto, ON, Canada
Univ Toronto, Inst Med Sci, Toronto, ON, CanadaUniv Hlth Network, Ajmera Transplant Program, Toronto, ON, Canada
Rabindranath, Madhumitha
;
Chara, Beatriz Sordi
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USAUniv Hlth Network, Ajmera Transplant Program, Toronto, ON, Canada
Chara, Beatriz Sordi
;
Simonetto, Douglas A.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USAUniv Hlth Network, Ajmera Transplant Program, Toronto, ON, Canada
机构:
Dumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Dumont UCLA Liver Canc Ctr, Dept Surg, Los Angeles, CA USA
Univ Chicago, Dept Surg, Sect Transplantat, 5841 S Maryland Ave, Chicago, IL 60637 USADumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Bodzin, Adam S.
;
Lunsford, Keri E.
论文数: 0引用数: 0
h-index: 0
机构:
Dumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Dumont UCLA Liver Canc Ctr, Dept Surg, Los Angeles, CA USA
Houston Methodist Hosp, Dept Surg, JC Walter Jr Ctr Transplantat, Houston, TX USADumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Lunsford, Keri E.
;
Markovic, Daniela
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Biomath, Los Angeles, CA 90095 USADumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Markovic, Daniela
;
Harlander-Locke, Michael P.
论文数: 0引用数: 0
h-index: 0
机构:
Dumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Dumont UCLA Liver Canc Ctr, Dept Surg, Los Angeles, CA USADumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Harlander-Locke, Michael P.
;
Busuttil, Ronald W.
论文数: 0引用数: 0
h-index: 0
机构:
Dumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Dumont UCLA Liver Canc Ctr, Dept Surg, Los Angeles, CA USADumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Busuttil, Ronald W.
;
Agopian, Vatche G.
论文数: 0引用数: 0
h-index: 0
机构:
Dumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
Dumont UCLA Liver Canc Ctr, Dept Surg, Los Angeles, CA USADumont UCLA Transplant Ctr, Dept Surg, Los Angeles, CA USA
机构:
Canc Surveillance Branch, Int Agcy Res Canc, Lyon, France
Int Agcy Res Canc IARC, Canc Surveillance Branch, 25 Ave Tony Garnier, F-69366 Lyon 07, FranceCanc Surveillance Branch, Int Agcy Res Canc, Lyon, France
Bray, Freddie
;
Laversanne, Mathieu
论文数: 0引用数: 0
h-index: 0
机构:
Canc Surveillance Branch, Int Agcy Res Canc, Lyon, FranceCanc Surveillance Branch, Int Agcy Res Canc, Lyon, France
Laversanne, Mathieu
;
Sung, Hyuna
论文数: 0引用数: 0
h-index: 0
机构:
Amer Canc Soc, Surveillance & Hlth Equ Sci, Atlanta, GA USACanc Surveillance Branch, Int Agcy Res Canc, Lyon, France
Sung, Hyuna
;
Ferlay, Jacques
论文数: 0引用数: 0
h-index: 0
机构:
Canc Surveillance Branch, Int Agcy Res Canc, Lyon, FranceCanc Surveillance Branch, Int Agcy Res Canc, Lyon, France
Ferlay, Jacques
;
Siegel, Rebecca L.
论文数: 0引用数: 0
h-index: 0
机构:
Amer Canc Soc, Surveillance & Hlth Equ Sci, Atlanta, GA USACanc Surveillance Branch, Int Agcy Res Canc, Lyon, France
Siegel, Rebecca L.
;
Soerjomataram, Isabelle
论文数: 0引用数: 0
h-index: 0
机构:
Canc Surveillance Branch, Int Agcy Res Canc, Lyon, FranceCanc Surveillance Branch, Int Agcy Res Canc, Lyon, France
Soerjomataram, Isabelle
;
Jemal, Ahmedin
论文数: 0引用数: 0
h-index: 0
机构:
Amer Canc Soc, Surveillance & Hlth Equ Sci, Atlanta, GA USACanc Surveillance Branch, Int Agcy Res Canc, Lyon, France
机构:
Henri Mondor Univ Hosp, AP HP, Dept Pathol, Creteil, France
INSERM, U955, F-94010 Creteil, France
Univ Paris Est Creteil, INSERM, IMRB, F-94010 Creteil, FranceHenri Mondor Univ Hosp, AP HP, Dept Pathol, Creteil, France
Calderaro, Julien
;
Seraphin, Tobias Paul
论文数: 0引用数: 0
h-index: 0
机构:
Heinrich Heine Univ Duesseldorf, Med Fac, Univ Hosp Duesseldorf, Dept Gastroenterol Hepatol & Infect Dis, Dusseldorf, GermanyHenri Mondor Univ Hosp, AP HP, Dept Pathol, Creteil, France
Seraphin, Tobias Paul
;
论文数: 引用数:
h-index:
机构:
Luedde, Tom
;
Simon, Tracey G.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Liver Ctr, Div Gastroenterol, 55 Fruit St,Wang 5th Floor, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit CTEU, Boston, MA 02114 USAHenri Mondor Univ Hosp, AP HP, Dept Pathol, Creteil, France
机构:
Hop Henri Mondor, AP HP, Unit Digest Hepatopancreatobiliary Surg & Liver T, F-94010 Creteil, France
Hop Henri Mondor, INSERM, U4394, MACBEth, F-94010 Creteil, France
Univ Naples Federico II, Dept Adv Biomed Sci, I-80138 Naples, ItalyHop Henri Mondor, AP HP, Unit Digest Hepatopancreatobiliary Surg & Liver T, F-94010 Creteil, France
de'Angelis, Nicola
;
Landi, Filippo
论文数: 0引用数: 0
h-index: 0
机构:
Hop Henri Mondor, AP HP, Unit Digest Hepatopancreatobiliary Surg & Liver T, F-94010 Creteil, FranceHop Henri Mondor, AP HP, Unit Digest Hepatopancreatobiliary Surg & Liver T, F-94010 Creteil, France
Landi, Filippo
;
论文数: 引用数:
h-index:
机构:
Carra, Maria Clotilde
;
Azoulay, Daniel
论文数: 0引用数: 0
h-index: 0
机构:
Hop Henri Mondor, AP HP, Unit Digest Hepatopancreatobiliary Surg & Liver T, F-94010 Creteil, France
Hop Henri Mondor, INSERM, U955, IMRB, F-94010 Creteil, FranceHop Henri Mondor, AP HP, Unit Digest Hepatopancreatobiliary Surg & Liver T, F-94010 Creteil, France