Linking vaccine adjuvant mechanisms of action to function

被引：15

作者：

Ben-Akiva, Elana ^{[1
,2
]}

Chapman, Asheley ^{[1
,2
,3
]}

Mao, Tianyang ^{[1
,2
]}

Irvine, Darrell J. ^{[1
,2
,3
,4
,5
]}

机构：

[1] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[2] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[3] Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA

[4] MIT, Broad Inst, Cambridge, MA 02139 USA

[5] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

来源：

SCIENCE IMMUNOLOGY | 2025年 / 10卷 / 104期

关键词：

B-CELL RESPONSES; INFLUENZA VACCINE; DENDRITIC CELLS; ANTIGEN; MEMORY; RNA; MACROPHAGES; TRANSPORT; IMPACT; ACTIVATION;

D O I：

10.1126/sciimmunol.ado5937

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaccines deliver an immunogen in a manner designed to safely provoke an immune response, leading to the generation of memory T and B cells and long-lived antibody-producing plasma cells. Adjuvants play a critical role in vaccines by controlling how the immune system is exposed to the immunogen and providing inflammatory cues that enable productive immune priming. However, mechanisms of action underlying adjuvant function at the molecular, cell, and tissue levels are diverse and often poorly understood. Here, we review the current understanding of mechanisms of action underlying adjuvants used in subunit protein/polysaccharide vaccines and mRNA vaccines, discuss where possible how these mechanisms of action link to downstream effects on the immune response, and identify knowledge gaps that will be important to fill in order to enable the continued development of more effective adjuvants for challenging pathogens such as HIV and emerging threats.

引用

页数：14

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