Multi-component reactions for the synthesis of current spiro-quinoxaline pyrrolizidine carboxylates via [3+2] cycloaddition reactions

被引：0

作者：

Shinde, Sundar S. ^{[1
]}

Deokar, Dipak B. ^{[1
]}

Laha, Soumi ^{[2
]}

Bhaskar, S. Uday ^{[2
]}

Sridhar, B. ^{[3
]}

Likhar, Pravin R. ^{[1
]}

机构：

[1] CSIR Indian Inst Chem Technol, Catalysis & Fine Chem Dept, Uppal Rd, Hyderabad 500007, India

[2] Malla Reddy Engn Coll Autonomous, Hyderabad 500010, Telengana, India

[3] CSIR Indian Inst Chem Technol, XRay Crystallog Ctr, Hyderabad 500007, India

来源：

ARKIVOC | 2024年

关键词：

Ninhydrin; o-phenylenediamine; L-proline; alkynes; DERIVATIVES; REGIO;

D O I：

10.24820/ark.5550190.p012.282

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel series of multi-component reactions (MCRs) has been devised for the synthesis of spiro-quinoxaline pyrrolizine compounds using ninhydrin, o-phenylenediamine, proline, and propiolate esters via a [3+2] cycloaddition process. This efficient one-pot sequential four-component synthesis demonstrates high performance in acetonitrile, yielding spiro-quinoxaline pyrrolizine derivatives with remarkable efficiency. Spiro-quinoxaline pyrrolizine structures represent versatile molecular frameworks with potential applications in drug discovery, showcasing intriguing features for scaffold diversification.

引用

页数：13

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