Organoselenium compounds beyond antioxidants

被引:2
作者
Mamgain, Ritu [1 ]
Mishra, Garima [2 ]
Kriti, Saumya [1 ]
Singh, Fateh V. [1 ]
机构
[1] Vellore Inst Technol Chennai, Sch Adv Sci SAS, Chem Div, Vandalur Kelambakkam Rd, Chennai 600127, Tamil Nadu, India
[2] Western Illinois Univ Quad Cities, Dept Chem, Moline, IL USA
关键词
Organoselenium compounds; anti-cancer; antithyroids; antimicrobial; anti-Alzheimer's; antiviral; Antidiabetic; IODOTHYRONINE DEIODINASE MIMICS; DEPRESSIVE-LIKE BEHAVIOR; GLUTATHIONE-PEROXIDASE; DIPHENYL DISELENIDE; REGIOSELECTIVE DEIODINATION; ANTIMICROBIAL ACTIVITY; BIOLOGICAL EVALUATION; ANTICANCER ACTIVITY; 1ST SYNTHESIS; SELENIUM;
D O I
10.1080/17568919.2024.2435254
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Organoselenium chemistry has become a significant field due to its role in synthesizing numerous biologically active and therapeutic compounds. In early phase, researchers focused on designing organoselenium compounds with antioxidant properties and were quite successful. In last two decades, synthetic chemists shifted their focus toward synthesis of organoselenium compounds with biological properties, moving beyond their traditional antioxidant properties. The review includes synthesis and study of organo-selenium compounds as anticancer, antimicrobial, antiviral, antidiabetic, antithyroid, anti-inflammatory therapies, contributing to disease treatment. This review covers the synthesis and medicinal applications of synthetic organoselenium compounds over the past 10 years, thus making it a valuable resource for researchers in the field of medicinal chemistry.
引用
收藏
页码:2663 / 2685
页数:23
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