Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment-The Role of Ceragenins in the Development of New Therapeutic Methods

被引:0
作者
Czarnowski, Michal [1 ]
Wnorowska, Urszula [1 ]
Luckiewicz, Milena [2 ]
Dargiewicz, Ewelina [3 ]
Spalek, Jakub [4 ]
Okla, Slawomir [4 ]
Sawczuk, Beata [5 ]
Savage, Paul B. [6 ]
Bucki, Robert [1 ]
Piktel, Ewelina [2 ]
机构
[1] Med Univ Bialystok, Dept Med Microbiol & Nanobiomed Engn, PL-15222 Bialystok, Poland
[2] Med Univ Bialystok, Independent Lab Nanomed, PL-15222 Bialystok, Poland
[3] Med Univ Bialystok, Dept Orthodont, PL-15269 Bialystok, Poland
[4] Jan Kochanowski Univ Kielce, Inst Med Sci, Coll Med, PL-25369 Kielce, Poland
[5] Med Univ Bialystok, Dept Prosthodont, PL-15276 Bialystok, Poland
[6] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA
关键词
antimicrobial peptides; oral cavity; ceragenins; PERIODONTAL-DISEASE; DENTAL-CARIES; ANTIBACTERIAL PROPERTIES; PSEUDOMONAS-AERUGINOSA; MOLECULAR ANALYSIS; BETA-DEFENSINS; EXPRESSION; CSA-13; BIOFILMS; LL-37;
D O I
10.3390/ph17121725
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Oral diseases, both acute and chronic, of infectious or non-infectious etiology, represent some of the most serious medical problems in dentistry. Data from the literature increasingly indicate that changes in the oral microbiome, and therefore, the overgrowing of pathological microflora, lead to a variety of oral-localized medical conditions such as caries, gingivitis, and periodontitis. In recent years, compelling research has been devoted to the use of natural antimicrobial peptides as therapeutic agents in the possible treatment of oral diseases. This review focuses on the potential of ceragenins (CSAs), which are lipid analogs of natural antimicrobial peptides, as molecules for the development of new methods for the prevention and treatment of oral diseases. Studies to date indicate that ceragenins, with their spectrum of multidirectional biological activities, including antimicrobial, tissue regeneration-stimulating, anti-inflammatory, and immunomodulatory properties, are strong candidates for further development of oral formulations. However, many of the beneficial properties of ceragenins require confirmation in experimental conditions reproducing the oral environment to fully determine their application potential. Their transition to practical use also requires more advanced testing of these molecules in clinical trials, which have only been conducted in limited numbers to date.
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页数:26
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共 175 条
[1]   Bacteria of dental caries in primary and permanent teeth in children and young adults [J].
Aas, Jorn A. ;
Griffen, Ann L. ;
Dardis, Sara R. ;
Lee, Alice M. ;
Olsen, Ingar ;
Dewhirst, Floyd E. ;
Leys, Eugene J. ;
Paster, Bruce J. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (04) :1407-1417
[2]  
Abdul Nishath Sayed, 2023, Cureus, V15, pe38398, DOI 10.7759/cureus.38398
[3]   Impact of COVID-19 vaccination on saliva immune barriers: IgA, lysozyme, and lactoferrin [J].
Abdul-Kareem H.H. ;
Al-Maqtoofi M.Y. ;
Burghal A.A. .
Archives of Virology, 2023, 168 (12)
[4]   Does human saliva decrease the antimicrobial activity of chlorhexidine against oral bacteria? [J].
Abouassi T. ;
Hannig C. ;
Mahncke K. ;
Karygianni L. ;
Wolkewitz M. ;
Hellwig E. ;
Al-Ahmad A. .
BMC Research Notes, 7 (1)
[5]   Structure and function of a serine carboxypeptidase adapted for degradation of the protein synthesis antibiotic microcin C7 [J].
Agarwal, Vinayak ;
Tikhonov, Anton ;
Metlitskaya, Anastasia ;
Severinov, Konstantin ;
Nair, Satish K. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (12) :4425-4430
[6]   Activatable prodrug for controlled release of an antimicrobial peptide via the proteases overexpressed in Candida albicans and Porphyromonas gingivalis [J].
Amer, Lubna ;
Retout, Maurice ;
Jokerst, Jesse V. .
THERANOSTICS, 2024, 14 (04) :1781-1793
[7]   Resistance Mechanisms to Antimicrobial Peptides in Gram-Positive Bacteria [J].
Assoni, Lucas ;
Milani, Barbara ;
Carvalho, Marianna Ribeiro ;
Nepomuceno, Lucas Natanael ;
Waz, Natalha Tedeschi ;
Guerra, Maria Eduarda Souza ;
Converso, Thiago Rojas ;
Darrieux, Michelle .
FRONTIERS IN MICROBIOLOGY, 2020, 11
[8]   The effect of nano silver fluoride, self-assembling peptide and sodium fluoride varnish on salivary cariogenic bacteria: a randomized controlled clinical trial [J].
Atteya, Sara M. ;
Amer, Hala A. ;
Saleh, Susan M. ;
Safwat, Yara .
CLINICAL ORAL INVESTIGATIONS, 2024, 28 (03)
[9]   Discovery of phosphorylated lantibiotics with proimmune activity that regulate the oral microbiome [J].
Barbour, Abdelahhad ;
Smith, Leif ;
Oveisi, Morvarid ;
Williams, McKinley ;
Huang, Ruo Chen ;
Marks, Cara ;
Fine, Noah ;
Sun, Chunxiang ;
Younesi, Fereshteh ;
Zargaran, Sina ;
Orugunty, Ravi ;
Horvath, Thomas D. ;
Haidacher, Sigmund J. ;
Haag, Anthony M. ;
Sabharwal, Amarpreet ;
Hinz, Boris ;
Glogauer, Michael .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 120 (22)
[10]   Antimicrobial Peptides: Mechanisms of Action and Resistance [J].
Bechinger, B. ;
Gorr, S. -U. .
JOURNAL OF DENTAL RESEARCH, 2017, 96 (03) :254-260