Toxicant Exposures and Health Symptoms in Military Pesticide Applicators From the 1991 Gulf War

被引：1

作者：

Krengel, Maxine ^{[1
,2
]}

Sullivan, Kimberly ^{[3
]}

Zundel, Clara G. ^{[1
,4
]}

Keating, Dylan ^{[3
]}

Orlinsky, Leah ^{[1
,3
]}

Bradford, William ^{[5
]}

Stone, Callie ^{[6
]}

Thompson, Terri-Ann ^{[7
]}

Heeren, Timothy ^{[8
]}

White, Roberta F. ^{[2
,3
,4
]}

机构：

[1] VA Boston Healthcare Syst, Boston, MA USA

[2] Boston Univ, Sch Med, Dept Neurol, 725 Albany St, Boston, MA 02118 USA

[3] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, 715 Albany St,T4W, Boston, MA 02118 USA

[4] Boston Univ, Sch Med, Behav Neurosci Program, Boston, MA USA

[5] Parsons Corp, Syracuse, NY USA

[6] Reliant Med Grp, Worcester, MA USA

[7] Ibis Reprod Hlth, Cambridge, MA USA

[8] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

来源：

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 2024年 / 66卷 / 11期

关键词：

Gulf War; pesticide; pyridostigmine bromide; health symptoms; acetylcholinesterase inhibitor; PYRIDOSTIGMINE BROMIDE; AUSTRALIAN VETERANS; CYCLOSARIN EXPOSURE; ILLNESS; SARIN; ASSOCIATION; WORKERS; SAMPLE;

D O I：

10.1097/JOM.0000000000003215

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

ObjectiveThe chronic impact of acetylcholinesterase inhibitors and other toxicants on Gulf War (GW) veterans' health symptoms is unclear.MethodsBuilding on reports of adverse neuropsychological outcomes in GW pesticide applicators exposed to pesticides and pyridostigmine bromide, we now report on health symptoms in this group.ResultsIn adjusted analyses, applicators with high exposures/impact to pesticides reported significantly more symptoms (18/34 symptoms) than applicators with lower exposures/impact and were more likely to meet modified Kansas and CDC Gulf War Illness criteria. The high pyridostigmine bromide exposure/impact group was 3 times more likely to report irregular heart rates. With regard to specific pesticide types, fly baits, pest strips, and delousers were the most associated with increased health symptom reporting.ConclusionsThese results suggest that GW veterans with high acetylcholinesterase inhibitor and organochlorine exposures are most at risk for chronic health symptoms.

引用

页码：e584 / e592

页数：9

共 42 条

[1] Association of Gulf War Illness-Related Symptoms with Military Exposures among 1990-1991 Gulf War Veterans Evaluated at the War-Related Illness and Injury Study Center (WRIISC) [J].