A gut feeling of statin

被引：3

作者：

She, Jianqing ^{[1
,2
,3
]}

Sun, Lizhe ^{[1
,2
]}

Yu, Yue ^{[1
,2
]}

Fan, Heze ^{[1
,2
]}

Li, Xia ^{[1
,2
]}

Zhang, Xinyu ^{[1
,2
]}

Zhuo, Xiaozhen ^{[1
,2
,3
]}

Guo, Manyun ^{[1
,2
]}

Liu, Junhui ^{[4
]}

Liu, Peining ^{[1
,2
]}

Tuerhongjiang, Gulinigaer ^{[1
,2
]}

Du, Bin ^{[1
,2
]}

Li, Hongbing ^{[1
,2
]}

Yu, Jun ^{[5
,6
]}

Yuan, Zuyi ^{[1
,2
]}

Wu, Yue ^{[1
,2
,3
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Cardiovasc Dept, Yanta West Rd 277, Xian 710000, Shaanxi, Peoples R China

[2] Minist Educ, Key Lab Environm & Genes Related Dis, Xian, Shaanxi, Peoples R China

[3] Minist Educ, Cardiometab Innovat Ctr, Xian, Shaanxi, Peoples R China

[4] Xi An Jiao Tong Univ, Affiliated Hosp 1, Clin Lab, Xian, Shaanxi, Peoples R China

[5] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China

[6] Chinese Univ Hong Kong, Inst Digest Dis, State Key Lab Digest Dis, Hong Kong, Peoples R China

来源：

GUT MICROBES | 2024年 / 16卷 / 01期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Statins; gut microbiota; drug metabolism; cardiovascular health; personalized treatment; LIPOPROTEIN CHOLESTEROL RESPONSE; HEART-FAILURE; MICROBIOTA; THERAPY; ATORVASTATIN; SIMVASTATIN; DIET; GENE; TRIMETHYLAMINE; ROSUVASTATIN;

D O I：

10.1080/19490976.2024.2415487

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Statins, known as HMG-CoA reductase inhibitors, are widely utilized to reduce blood cholesterol levels and possess pleiotropic effects, including the influence on inflammation and macrophage proliferation. Despite their significant impact in diminishing the incidence of cardiovascular events and mortality, individual responses to statin therapy vary considerably. Understanding this variability is essential for optimizing treatment outcomes and minimizing adverse effects. The gut microbiota, a complex ecosystem of microorganisms within the gastrointestinal tract, plays a critical role in human health and disease. Emerging evidence has linked the gut microbiota to drug metabolism and response, with the potential to modulate the efficacy of statin therapy and its side effects. This review provides a comprehensive overview of the interaction between the gut microbiota and statins. It discusses how the gut microbiota can influence the therapeutic effects and side effects of statins and examines the mechanisms by which the gut microbiota affect statin response and cardiovascular diseases.

引用

页数：16

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