Gold-silver bimetallic nanoparticles conjugated to asymmetric porphyrin for photodynamic therapy against triple negative breast cancer

被引：1

作者：

Magaela, N. Bridged ^{[1
]}

Managa, Muthumuni ^{[2
]}

Nyokong, Tebello ^{[1
]}

机构：

[1] Rhodes Univ, Inst Nanotechnol Innovat, ZA-6140 Makhanda, South Africa

[2] Univ South Afr, Inst Nanotechnol & Water Sustainabil iNanoWS, Coll Sci, Florida Campus, ZA-1710 Johannesburg, South Africa

来源：

JOURNAL OF LUMINESCENCE | 2025年 / 280卷

基金：

新加坡国家研究基金会;

关键词：

Photodynamic therapy; Bimetallic nanoparticles; singlet oxygen; MDA-MB-231 cancer cell line; QUANTUM YIELD MEASUREMENTS; GREEN SYNTHESIS; AU; AG; MECHANISM;

D O I：

10.1016/j.jlumin.2025.121065

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

5, 10, 15-Tris (4-nitrophenyl)-20-hydroxylphenylporphyrin (complex 1) was synthesized and metalated with gallium chloride (complex 2). These porphyrin complexes were then conjugated to biotin decorated gold-silver bimetallic nanoparticles (B-Au-Ag) to enhance photodynamic therapy efficiency. The photophysical properties of the porphyrin complexes and their conjugates were studied, and it was observed that the presence of (B-Au-Ag) enhanced the singlet oxygen quantum yield resulting in values of 0.60 and 0.74 for 1-B-Au-Ag and 2-B-Au-Ag, respectively. It was also observed that B-Au-Ag nanoparticles are more stable resulting in higher zeta potential when compared to the porphyrin conjugates. 2-B-Au-Ag resulted with lowest cell viability of 24.67% when compared to all other photosensitizes.

引用

页数：12

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