Lipid metabolism in MASLD and MASH: From mechanism to the clinic

被引：26

作者：

Carli, Fabrizia ^{[1
]}

Della Pepa, Giuseppe ^{[1
]}

Sabatini, Silvia ^{[1
]}

Puig, Antonio Vidal ^{[2
,3
,4
]}

Gastaldelli, Amalia ^{[1
]}

机构：

[1] Natl Res Council CNR, Inst Clin Physiol IFC, Cardiometab Risk Lab, Pisa, Italy

[2] Univ Cambridge, Med Res Council Inst Metab Sci, Metab Res Labs, Wellcome Med Res Council, Cambridge CB2 0QQ, England

[3] Ctr Invest Principe Felipe, Valencia 46012, Spain

[4] Univ Cambridge, Nanjing Ctr Technol & Innovat, Nanjing, Peoples R China

来源：

JHEP REPORTS | 2024年 / 6卷 / 12期

基金：

欧盟地平线“2020”;

关键词：

Non-esterified fatty acids; de novo lipogenesis; mitochondrial function; diet composition; hepatic lipid metabolism; NONALCOHOLIC FATTY-LIVER; DE-NOVO LIPOGENESIS; TISSUE INSULIN-RESISTANCE; ADIPOSE-TISSUE; NONDIABETIC PATIENTS; CONTROLLED-TRIAL; INTRAMYOCELLULAR CERAMIDES; HEPATIC STEATOSIS; WEIGHT-LOSS; TCA CYCLE;

D O I：

10.1016/j.jhepr.2024.101185

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Metabolic dysfunction-associated steatotic liver disease/steatohepatitis (MASLD/MASH) is recognised as a metabolic disease characterised by excess intrahepatic lipid accumulation due to lipid overflow and synthesis, alongside impaired oxidation and/or export of these lipids. But where do these lipids come from? The main pathways related to hepatic lipid accumulation are de novo lipogenesis and excess fatty acid transport to the liver (due to increased lipolysis, adipose tissue insulin resistance, as well as excess dietary fatty acid intake, in particular of saturated fatty acids). Not only triglycerides but also other lipids are secreted by the liver and are associated with a worse histological profile in MASH, as shown by lipidomics. Herein, we review the role of lipid metabolism in MASLD/MASH and discuss the impact of weight loss (diet, bariatric surgery, GLP-1RAs) or other pharmacological treatments (PPAR or THRb agonists) on hepatic lipid metabolism, lipidomics, and the resolution of MASH. (c) 2024 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页数：16

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