The Effect of Maternal Diet and Lifestyle on the Risk of Childhood Obesity

被引:1
作者
Luszczki, Edyta [1 ]
Wyszynska, Justyna [1 ]
Dymek, Agnieszka [1 ]
Drozdz, Dorota [2 ]
Gonzalez-Ramos, Laura [3 ]
Hartgring, Isa [3 ]
Garcia-Carbonell, Nuria [3 ,4 ]
Mazur, Artur [5 ]
Erdine, Serap [6 ]
Parnarauskiene, Juste [7 ]
Alvarez-Pitti, Julio [3 ,4 ,8 ]
eprObes Consortium
机构
[1] Rzeszow Univ, Inst Hlth Sci, Med Coll, PL-35959 Rzeszow, Poland
[2] Jagiellonian Univ, Pediat Inst, Med Coll, Dept Pediat Nephrol & Hypertens, PL-31007 Krakow, Poland
[3] Univ Valencia, Consorcio Hosp Gen, Fdn Invest, Innovat Paediat & Technol iPEDITEC Res Grp, Valencia 46010, Spain
[4] Univ Valencia, Consorcio Hosp Gen, Pediat Dept, Valencia 46014, Spain
[5] Rzeszow Univ, Inst Med Sci, Med Coll, PL-35959 Rzeszow, Poland
[6] Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Dept Cardiol, TR-34320 Istanbul, Turkiye
[7] Vilnius Univ Hosp St Klin, Pediat Dept, LT-08661 Vilnius, Lithuania
[8] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain
关键词
childhood obesity; fetal programming; epigenetics; maternal lifestyle; maternal diet; gut microbiota; gestational diabetes; obesogenes; OFFSPRING BODY-COMPOSITION; GUT MICROBIOME; NONCODING RNAS; DEVELOPMENTAL ORIGINS; CARDIOMETABOLIC RISK; DNA METHYLATION; GLYCEMIC INDEX; PREGNANCY; HEALTH; ASSOCIATIONS;
D O I
10.3390/metabo14120655
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background/Objectives: Childhood obesity is a global health problem that affects at least 41 million children under the age of five. Increased BMI in children is associated with serious long-term health consequences, such as type 2 diabetes, cardiovascular disease, and psychological problems, including depression and low self-esteem. Although the etiology of obesity is complex, research suggests that the diet and lifestyle of pregnant women play a key role in shaping metabolic and epigenetic changes that can increase the risk of obesity in their children. Excessive gestational weight gain, unhealthy dietary patterns (including the Western diet), and pregnancy complications (such as gestational diabetes) are some of the modifiable factors that contribute to childhood obesity. The purpose of this narrative review is to summarize the most important and recent information on the impact of the diet and lifestyle of pregnant women on the risk of childhood obesity. Methods: This article is a narrative review that aims to summarize the available literature on the impact of pregnant women's diet and lifestyle on the risk of obesity in their offspring, with a focus on metabolic and epigenetic mechanisms. Results/Conclusions: Current evidence suggests that a pregnant woman's lifestyle and diet can significantly contribute to lowering the risk of obesity in their offspring. However, further high-quality research is needed to understand better the metabolic and epigenetic relationships concerning maternal factors that predispose offspring to obesity.
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页数:20
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