Altered regional brain activity and functional connectivity in primary intravaginal anejaculation patients revealed by resting-state fMRI

被引：0
作者：
Gao, Qing-Qiang [1 ,2 ]
Chen, Jian-Huai [3 ]
Lu, Jia-Ming [4 ]
Wang, Bin [2 ]
Han, You-Feng [2 ]
Gao, Song-Zhan [5 ]
Yang, Jie [6 ,7 ]
Dai, Yu-Tian [1 ,2 ]
机构：
[1] Nanjing Med Univ, Nanjing Drum Tower Hosp, Clin Coll, Nanjing 210008, Peoples R China
[2] Nanjing Univ, Nanjing Drum Tower Hosp, Dept Androl, Affiliated Hosp,Med Sch, Nanjing 210008, Peoples R China
[3] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Dept Androl, Affiliated Hosp, Nanjing 210029, Peoples R China
[4] Nanjing Univ, Nanjing Drum Tower Hosp, Dept Radiol, Affiliated Hosp,Med Sch, Nanjing 210008, Peoples R China
[5] Zhengzhou Univ, Dept Androl, Affiliated Hosp 3, Zhengzhou 450052, Peoples R China
[6] Nanjing Med Univ, Jiangsu Prov Peoples Hosp, Dept Urol, Affiliated Hosp 1, Nanjing 210029, Peoples R China
[7] Peoples Hosp Xinjiang Kizilsu Kirgiz Autonomous P, Dept Urol, Xinjiang 845350, Kizilsu Kirgiz, Peoples R China
来源：
ASIAN JOURNAL OF ANDROLOGY | 2024年 / 26卷 / 05期
关键词：
fractional amplitude of low-frequency fluctuation; functional connectivity; primary intravaginal anejaculation; regional homogeneity; resting-state functional magnetic resonance imaging; PREMATURE EJACULATION; SEXUAL STIMULATION; ACTIVATION; PHYSIOLOGY; DISORDERS; NETWORKS;
D O I：
10.4103/aja202413
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
Ejaculation is regulated by the central nervous system. However, the central pathophysiology of primary intravaginal anejaculation (PIAJ) is unclear. The present study aimed to examine the changes in regional brain activity and functional connectivity underlying PIAJ. A total of 20 PIAJ patients and 16 healthy controls (HCs) were enrolled from September 2020 to September 2022 in the Department of Andrology, Nanjing Drum Tower Hospital (Nanjing, China). Magnetic resonance imaging data were acquired from all participants and then were preprocessed. The measures of fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and functional connectivity (FC) were calculated and compared between the groups. PIAJ patients showed increased fALFF values in the left precuneus compared with HCs. Additionally, PIAJ patients showed increased ReHo values in the left precuneus, left postcentral gyrus, left superior occipital gyrus, left calcarine fissure, right precuneus, and right middle temporal gyrus, and decreased ReHo values in the left inferior parietal gyrus, compared with HCs. Finally, brain regions with altered fALFF and ReHo values in PIAJ patients showed increased FC with widespread cortical regions, which included the frontal, parietal, temporal, and occipital regions, compared with HCs. In conclusion, increased regional brain activity in the parietal, temporal, and occipital regions, and increased FC between these brain regions, may be associated with PIAJ occurrence.
引用
收藏
页码：510 / 516
页数：7
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