Prostate cancer and genetic contributions

被引：0

作者：

Chou, Wesley H. ^{[1
]}

Chalker, Cameron ^{[2
]}

Sokolova, Alexandra O. ^{[2
]}

Isharwal, Sudhir ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Urol, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Sch Med, Div Hematol Med Oncol, Portland, OR USA

来源：

ANDROLOGY | 2025年 / 13卷 / 05期

关键词：

genetic testing; germline mutations; prostate cancer; PLATINUM-BASED CHEMOTHERAPY; LYNCH SYNDROME; DNA-REPAIR; BRCA MUTATIONS; RISK; GERMLINE; MEN; HOXB13; BREAST; VARIANTS;

D O I：

10.1111/andr.13812

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Prostate cancer remains a lethal disease for many men. Knowledge of genetic contributions to this condition has increasingly been used in its management. In this narrative review, we summarize various genetic alterations and syndromes associated with prostate cancer, including hereditary breast and ovarian cancer syndrome, Lynch syndrome, and hereditary prostate cancer, among others. Indications for germline testing are reviewed, as well as incorporation of genetic data at different phases of management for prostate cancer, such as screening and monitoring, and treatment of localized and metastatic disease.

引用

页码：1149 / 1157

页数：9

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