Unresolved ethical issues of genetic counseling and testing in clinical psychiatry

被引:0
作者
Perry, Julia [1 ]
Bunnik, Eline [2 ]
Rietschel, Marcella [3 ]
Bentzen, Heidi Beate [4 ]
Ingvoldstad Malmgren, Charlotta [5 ,6 ]
Pawlak, Joanna [7 ]
Chaumette, Boris [8 ]
Tammimies, Kristiina [9 ,10 ]
Bialy, Filip [11 ,12 ]
Bizzarri, Virginia [13 ]
Borg, Isabella [14 ,15 ,16 ]
Coviello, Domenico [17 ]
Crepaz-Keay, David [18 ]
Ivanova, Eliza [19 ]
Mcquillin, Andrew [20 ]
Mezinska, Signe [21 ]
Johansson Soller, Maria [6 ,22 ]
Suvisaari, Jaana [23 ]
Watson, Melanie [24 ]
Wirgenes, Katrine [25 ]
Wynn, Sarah L. [26 ]
Degenhardt, Franziska [27 ,28 ]
Schicktanz, Silke [1 ]
机构
[1] Univ Med Ctr Gottingen, Dept Med Eth & Hist Med, Humboldtallee 36, D-37073 Gottingen, Germany
[2] Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands
[3] Heidelberg Univ, Cent Inst Mental Hlth, Fac Med Mannheim, Dept Genet epidemiol Psychiat, Mannheim, Germany
[4] Univ Oslo, Fac Med, Ctr Med Eth, Oslo, Norway
[5] Uppsala Univ, Ctr Res Eth & Bioeth CRB, Dept Publ Hlth & Caring Sci, Uppsala, Sweden
[6] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
[7] Poznan Univ Med Sci, Dept Psychiat Genet, PL-61701 Poznan, Poland
[8] Univ Paris, INSERM U1266, Inst Psychiat & Neurosci Paris, Inst Pasteur Humann Genet & Cognit Funct,CNRS UMR3, Paris, France
[9] Karolinska Inst, Karolinska Inst KIND, Karolinska Inst Ctr Neurodev Disorders KIND, Stockholm, Sweden
[10] Karolinska Univ Hosp, Astrid Lindgrens Children Hosp, Stockholm, Sweden
[11] Adam Mickiewicz Univ, Coll Polonicum, PL-69100 Poznan, Poland
[12] Univ Manchester, Dept Polit, Manchester, England
[13] ASL3, Dept Mental Hlth & Pathol Addict Neuropsychiat Chi, Avellino, Italy
[14] Univ Malta, Fac Med & Surg, Dept Pathol, Msida, Malta
[15] Mater Dei Hosp, Dept Nephrol & Gen Med, L Imsida, Malta
[16] Univ Malta, Fac Med & Surg, Ctr Mol Med & Biobanking, Msida, Malta
[17] IRCCS Ist Giannina Gaslini, Lab Human Genet, Genoa, Italy
[18] Mental Hlth Fdn, London, England
[19] Sofia Univ St Kliment Ohridski, Fac Philosophy, Dept Gen Expt Dev & Hlth Psychol, Sofia, Bulgaria
[20] UCL, Div Psychiat, London, England
[21] Univ Latvia, Inst Clin & Prevent Med, Riga, Latvia
[22] Karolinska Univ Hosp, Dept Clin Genet & Genom, Med Diagnost, Stockholm, Sweden
[23] Finnish Inst Hlth & Welf, Dept Healthcare & Social Welf, Helsinki, Finland
[24] Univ Hosp Southampton NHS Fdn Trust, Wessex Clin Genet Serv, Southampton, England
[25] Oslo Univ Hosp, Dept Med Genet, Oslo, Norway
[26] Unique Rare Chromosome Disorder Support Grp, Surrey CR3 5GN, England
[27] Univ Duisburg Essen, Univ Hosp Essen, Dept Child & Adolescent Psychiat Psychosomat & Ps, Duisburg, Germany
[28] Univ Bonn, Inst Human Genet, Bonn, Germany
关键词
clinical psychiatry; ethics; genetic counseling; genetic testing; recommendations; MENTAL-ILLNESS STIGMA; POLYGENIC RISK SCORES; DISORDERS; ATTITUDES; VARIANTS; IMPACT; SCHIZOPHRENIA; INDIVIDUALS; PREFERENCES; INFORMATION;
D O I
10.1097/YPG.0000000000000385
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
ObjectiveThis position article discusses current major ethical and social issues related to genetic counseling and testing in clinical psychiatry (PsyGCT).MethodsTo address these complex issues in the context of clinical psychiatry relevant to PsyGCT, the interdisciplinary and pan-European expert Network EnGagE (Enhancing Psychiatric Genetic Counseling, Testing, and Training in Europe; CA17130) was established in 2018. We conducted an interdisciplinary, international workshop at which we identified gaps across European healthcare services and research in PsyGCT; the workshop output was summarized and systematized for this position article.ResultsFour main unresolved ethical topics were identified as most relevant for the implementation of PsyGCT: (1) the problematic dualism between somatic and psychiatric disorders, (2) the impact of genetic testing on stigma, (3) fulfilling professional responsibilities, and (4) ethical issues in public health services. We provide basic recommendations to inform psychiatrists and other healthcare professionals involved in the clinical implementation of PsyGCT and conclude by pointing to avenues of future ethics research in PsyGCT.ConclusionThis article draws attention to a set of unresolved ethical issues relevant for mental health professionals, professionals within clinical genetics, patients and their family members, and society as a whole and stresses the need for more interdisciplinary exchange to define standards in psychiatric counseling as well as in public communication. The use of PsyGCT may, in the future, expand and include genetic testing for additional psychiatric diagnoses. We advocate the development of pan-European ethical standards addressing the four identified areas of ethical-practical relevance in PsyGCT.
引用
收藏
页码:26 / 36
页数:11
相关论文
共 120 条
  • [1] New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
    Andreassen, Ole A.
    Hindley, Guy F. L.
    Frei, Oleksandr
    Smeland, Olav B.
    [J]. WORLD PSYCHIATRY, 2023, 22 (01) : 4 - 24
  • [2] Can we end stigma and discrimination in mental health?
    不详
    [J]. LANCET, 2022, 400 (10361) : 1381 - 1381
  • [3] [Anonymous], 1997, CONVENTION PROTECTIO
  • [4] [Anonymous], 2008, Additional Protocol to the Convention on Human Rights and Biomedicine, concerning Genetic Testing for Health Purposes
  • [5] Analysis of shared heritability in common disorders of the brain
    Anttila, Verneri
    Bulik-Sullivan, Brendan
    Finucane, Hilary K.
    Walters, Raymond K.
    Bras, Jose
    Duncan, Laramie
    Escott-Price, Valentina
    Falcone, Guido J.
    Gormley, Padhraig
    Malik, Rainer
    Patsopoulos, Nikolaos A.
    Ripke, Stephan
    Wei, Zhi
    Yu, Dongmei
    Lee, Phil H.
    Turley, Patrick
    Grenier-Boley, Benjamin
    Chouraki, Vincent
    Kamatani, Yoichiro
    Berr, Claudine
    Letenneur, Luc
    Hannequin, Didier
    Amouyel, Philippe
    Boland, Anne
    Deleuze, Jean-Francois
    Duron, Emmanuelle
    Vardarajan, Badri N.
    Reitz, Christiane
    Goate, Alison M.
    Huentelman, Matthew J.
    Kamboh, M. Ilyas
    Larson, Eric B.
    Rogaeva, Ekaterina
    St George-Hyslop, Peter
    Hakonarson, Hakon
    Kukull, Walter A.
    Farrer, Lindsay A.
    Barnes, Lisa L.
    Beach, Thomas G.
    Demirci, F. Yesim
    Head, Elizabeth
    Hulette, Christine M.
    Jicha, Gregory A.
    Kauwe, John S. K.
    Kaye, Jeffrey A.
    Leverenz, James B.
    Levey, Allan I.
    Lieberman, Andrew P.
    Pankratz, Vernon S.
    Poon, Wayne W.
    [J]. SCIENCE, 2018, 360 (6395) : 1313 - +
  • [6] Anticipating the Ethical Challenges of Psychiatric Genetic Testing
    Appelbaum, Paul S.
    Benston, Shawna
    [J]. CURRENT PSYCHIATRY REPORTS, 2017, 19 (07)
  • [7] The potential impact of genetic counseling for mental illness
    Austin, JC
    Honer, WG
    [J]. CLINICAL GENETICS, 2005, 67 (02) : 134 - 142
  • [8] Evidence-Based Genetic Counseling for Psychiatric Disorders: A Road Map
    Austin, Jehannine C.
    [J]. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2020, 10 (06):
  • [9] Austin Jehannine C, 2008, J Genet Couns, V17, P18, DOI 10.1007/s10897-007-9121-4