Antimicrobial polyketides from an endophytic fungus Arcopilus aureus HJ-7 from Ardisia mamillata Hance

被引：0
作者：
Liang, Li-Qi [1 ]
He, Xian-Hua [1 ]
Wei, Chun-Yan [1 ]
Zhao, Jing-Xian [1 ]
Wu, Qian [1 ]
Liang, Min [1 ]
Li, Jun [1 ]
Luo, Yan [2 ]
Xu, Wei-Feng [1 ]
Yang, Rui-Yun [1 ]
机构：
[1] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, Collaborat Innovat Ctr Guangxi Ethn Med, State Key Lab Chem & Mol Engn Med Resources,Key La, Guilin, Peoples R China
[2] Guangxi Med Univ, Life Sci Inst, Collaborat Innovat Ctr Regenerat Med & Med BioReso, Nanning, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2024年
基金：
中国国家自然科学基金;
关键词：
Arcopilus aureus; antibacterial activities; antifungal activities; polyketides; PENICILLIUM; BIOSYNTHESIS; PRODUCTS; PIGMENTS;
D O I：
10.1080/14786419.2024.2429119
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Eleven polyketide derivatives, including two new compounds, xanthoradone D (1) and arisochromophilone (2), were isolated from Arcopilus aureus HJ-7, a Chinese medicinal plant Ardisia mamillata Hance-associated fungus. Their structures were elucidated on the basis of spectroscopic analysis and ECD (Electronic Circular Dichroism) calculations. The antibacterial and antifungal activities of the compounds were evaluated. Compound 1 showed the significant inhibitory activity against Staphylococcus aureus and Xanthomonas axonopodis pv. citri (Hasse) Dye with the MIC (Minimum Inhibitory Concentration) value of 6.25 mu g/mL, and 1 also showed strong antifungal activities against Cochliobolus miyabeanus and Ceratocystis paradoxa with the MIC value of 3.125 mu g/mL.
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